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PQBP1

GENERAL INFORMATION

Gene name

 PQBP1

Gene description

 Polyglutamine binding protein 1

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA001880
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and cervical cancer (favourable).
Renal cancer p<0.001
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001880

GENE INFORMATION

Gene name

 PQBP1 (HGNC Symbol)

Synonyms

 MRX2, MRX55, MRXS8, RENS1, SHS

Description

 Polyglutamine binding protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a nuclear polyglutamine-binding protein that is involved with transcription activation. The encoded protein contains a WW domain. Mutations in this gene have been found in patients with Renpenning syndrome 1 and other syndromes with X-linked mental retardation. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.[provided by RefSeq, Nov 2009]

Chromosome

 X

Cytoband

 p11.23

Chromosome location (bp)

 48897912 - 48903143

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102103 (version 83.38)

Entrez gene

 10084

UniProt

 O60828 (UniProt - Evidence at protein level)

neXtProt

 NX_O60828

Antibodypedia

 PQBP1 antibodies

PROTEIN BROWSER
PQBP1-001
PQBP1-002
PQBP1-007
PQBP1-011
PQBP1-201
PQBP1-202
PQBP1-203
PQBP1-204

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PQBP1-001
ENSP00000391759
ENST00000447146
O60828 [Direct mapping]
Polyglutamine-binding protein 1
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000380 [alternative mRNA splicing, via spliceosome]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016607 [nuclear speck]
GO:0031175 [neuron projection development]
GO:0043021 [ribonucleoprotein complex binding]
GO:0043484 [regulation of RNA splicing]
Show all
 265 aa
30.5 kDa 		No 0
PQBP1-002
ENSP00000247140
ENST00000247140
O60828 [Direct mapping]
Polyglutamine-binding protein 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000380 [alternative mRNA splicing, via spliceosome]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016607 [nuclear speck]
GO:0031175 [neuron projection development]
GO:0043021 [ribonucleoprotein complex binding]
GO:0043484 [regulation of RNA splicing]
Show all
 170 aa
18.8 kDa 		No 0
PQBP1-007
ENSP00000393013
ENST00000456306
H7C053 [Direct mapping]
Polyglutamine-binding protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 150 aa
16.5 kDa 		No 0
PQBP1-011
ENSP00000414861
ENST00000443648
C9JQA1 [Direct mapping]
Polyglutamine-binding protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0034063 [stress granule assembly]
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 213 aa
24.9 kDa 		No 0
PQBP1-201
ENSP00000218224
ENST00000218224
O60828 [Direct mapping]
Polyglutamine-binding protein 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000380 [alternative mRNA splicing, via spliceosome]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008022 [protein C-terminus binding]
GO:0010494 [cytoplasmic stress granule]
GO:0016607 [nuclear speck]
GO:0031175 [neuron projection development]
GO:0043021 [ribonucleoprotein complex binding]
GO:0043484 [regulation of RNA splicing]
GO:0048814 [regulation of dendrite morphogenesis]
GO:0060271 [cilium morphogenesis]
GO:0071598 [neuronal ribonucleoprotein granule]
GO:0072372 [primary cilium]
GO:0097546 [ciliary base]
Show all
 265 aa
30.5 kDa 		No 0
PQBP1-202
ENSP00000365747
ENST00000376563
O60828 [Direct mapping]
Polyglutamine-binding protein 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000380 [alternative mRNA splicing, via spliceosome]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016607 [nuclear speck]
GO:0031175 [neuron projection development]
GO:0043021 [ribonucleoprotein complex binding]
GO:0043484 [regulation of RNA splicing]
Show all
 265 aa
30.5 kDa 		No 0
PQBP1-203
ENSP00000365750
ENST00000376566
O60828 [Direct mapping]
Polyglutamine-binding protein 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000380 [alternative mRNA splicing, via spliceosome]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016607 [nuclear speck]
GO:0031175 [neuron projection development]
GO:0043021 [ribonucleoprotein complex binding]
GO:0043484 [regulation of RNA splicing]
Show all
 170 aa
18.8 kDa 		No 0
PQBP1-204
ENSP00000379985
ENST00000396763
O60828 [Direct mapping]
Polyglutamine-binding protein 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000380 [alternative mRNA splicing, via spliceosome]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016607 [nuclear speck]
GO:0031175 [neuron projection development]
GO:0043021 [ribonucleoprotein complex binding]
GO:0043484 [regulation of RNA splicing]
Show all
 265 aa
30.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.