Cell atlas - SMS - The Human Protein Atlas

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SMS

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nuclear bodies

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	SMS
Gene description	Spermine synthase
Protein class	Disease related genes Enzymes FDA approved drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear bodies. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear bodies (approved)
Additional location	In addition localized to the Cytosol (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA029852
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear bodies. In addition localized to the cytosol.

Main location

Nuclear bodies (approved)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA029852	A-431	Nuclear bodies	Intensity
	HPA029852	U-2 OS	Nuclear bodies	Intensity
	HPA029852	U-251 MG	Nuclear bodies	Intensity
	HPA029852	U-251 MG	Cytosol

GENE INFORMATION
Gene name	SMS (HGNC Symbol)
Synonyms	MRSR, SPMSY, SpS, SRS
Description	Spermine synthase (HGNC Symbol)
Entrez gene summary	This gene encodes a protein belonging to the spermidine/spermin synthase family. Pseudogenes of this gene are located on chromosomes 1, 5, 6 and X. Mutations in this gene are associated with X-linked Snyder-Robinson mental retardation syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Chromosome	X
Cytoband	p22.11
Chromosome location (bp)	21940573 - 21994835
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000102172 (version 83.38)
Entrez gene	6611
UniProt	P52788 (UniProt - Evidence at protein level)
neXtProt	NX_P52788
Antibodypedia	SMS antibodies

PROTEIN BROWSER

SMS-002	SMS-003	SMS-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SMS-002 ENSP00000368714 ENST00000379404	P52788 [Direct mapping] Spermine synthase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0005829 [cytosol] GO:0006555 [methionine metabolic process] GO:0006595 [polyamine metabolic process] GO:0006597 [spermine biosynthetic process] GO:0016768 [spermine synthase activity] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	313 aa 35.3 kDa	No	0
SMS-003 ENSP00000385746 ENST00000404933	P52788 [Direct mapping] Spermine synthase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005829 [cytosol] GO:0006555 [methionine metabolic process] GO:0006595 [polyamine metabolic process] GO:0006597 [spermine biosynthetic process] GO:0016768 [spermine synthase activity] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	366 aa 41.3 kDa	No	0
SMS-004 ENSP00000407366 ENST00000457085	H7C2R7 [Direct mapping] Spermine synthase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006597 [spermine biosynthetic process] GO:0016768 [spermine synthase activity] Show all	311 aa 33.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.