Expression of SMS in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SMS
Gene description	Spermine synthase
Protein class	Disease related genes Enzymes FDA approved drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct expression of ovarian follicles. Also expressed in testis, prostate and in several other tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification. Correlation with RNA expression data cannot be evaluated due to cell type not available.
Reliability score	Approved based on 2 antibodies. HPA029849 , HPA029852
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), renal cancer (unfavourable) and head and neck cancer (unfavourable).
Liver cancer p<0.001 Renal cancer p<0.001 Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA029849	HPA029852

GENE INFORMATION
Gene name	SMS (HGNC Symbol)
Synonyms	MRSR, SPMSY, SpS, SRS
Description	Spermine synthase (HGNC Symbol)
Entrez gene summary	This gene encodes a protein belonging to the spermidine/spermin synthase family. Pseudogenes of this gene are located on chromosomes 1, 5, 6 and X. Mutations in this gene are associated with X-linked Snyder-Robinson mental retardation syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Chromosome	X
Cytoband	p22.11
Chromosome location (bp)	21940573 - 21994835
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000102172 (version 83.38)
Entrez gene	6611
UniProt	P52788 (UniProt - Evidence at protein level)
neXtProt	NX_P52788
Antibodypedia	SMS antibodies

PROTEIN BROWSER

SMS-002	SMS-003	SMS-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SMS-002 ENSP00000368714 ENST00000379404	P52788 [Direct mapping] Spermine synthase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0005829 [cytosol] GO:0006555 [methionine metabolic process] GO:0006595 [polyamine metabolic process] GO:0006597 [spermine biosynthetic process] GO:0016768 [spermine synthase activity] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	313 aa 35.3 kDa	No	0
SMS-003 ENSP00000385746 ENST00000404933	P52788 [Direct mapping] Spermine synthase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005829 [cytosol] GO:0006555 [methionine metabolic process] GO:0006595 [polyamine metabolic process] GO:0006597 [spermine biosynthetic process] GO:0016768 [spermine synthase activity] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	366 aa 41.3 kDa	No	0
SMS-004 ENSP00000407366 ENST00000457085	H7C2R7 [Direct mapping] Spermine synthase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006597 [spermine biosynthetic process] GO:0016768 [spermine synthase activity] Show all	311 aa 33.4 kDa	No	0