Expression of GPR50 in cancer - Summary - The Human Protein Atlas

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GPR50

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GPR50
Gene description	G protein-coupled receptor 50
Protein class	G-protein coupled receptors Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enriched (HEK93)
HPA (normal tissue):	Not detected

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Highly expressed in the pituitary gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Presumed off target binding observed and disregarded. Antibody staining consistent with external characterization data and GTEx RNA expression data. Pending retesting.
Reliability score	Supported based on 2 antibodies. HPA049862 , HPA054678
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA049862	HPA054678

GENE INFORMATION
Gene name	GPR50 (HGNC Symbol)
Synonyms	H9, Mel1c
Description	G protein-coupled receptor 50 (HGNC Symbol)
Entrez gene summary	This gene product belongs to the G-protein coupled receptor 1 family. Even though this protein shares similarity with the melatonin receptors, it does not bind melatonin, however, it inhibits melatonin receptor 1A function through heterodimerization. Polymorphic variants of this gene have been associated with bipolar affective disorder in women. [provided by RefSeq, Jan 2010]
Chromosome	X
Cytoband	q28
Chromosome location (bp)	151176653 - 151181465
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000102195 (version 83.38)
Entrez gene	9248
UniProt	Q13585 (UniProt - Evidence at protein level)
neXtProt	NX_Q13585
Antibodypedia	GPR50 antibodies

PROTEIN BROWSER

GPR50-001	GPR50-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPR50-001 ENSP00000218316 ENST00000218316	Q13585 [Direct mapping] Melatonin-related receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0008502 [melatonin receptor activity] GO:0016021 [integral component of membrane] GO:0042802 [identical protein binding] Show all	617 aa 67.4 kDa	No	7
GPR50-201 ENSP00000484496 ENST00000617907	A0A087X1V7 [Direct mapping] Melatonin-related receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0008502 [melatonin receptor activity] GO:0016021 [integral component of membrane] Show all	615 aa 67.3 kDa	No	7

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.