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CDK16

GENERAL INFORMATION

Gene name

 CDK16

Gene description

 Cyclin-dependent kinase 16

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 14
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression at variable levels.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA001366 , CAB016535
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001366
CAB016535

GENE INFORMATION

Gene name

 CDK16 (HGNC Symbol)

Synonyms

 FLJ16665, PCTAIRE, PCTAIRE1, PCTGAIRE, PCTK1

Description

 Cyclin-dependent kinase 16 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2009]

Chromosome

 X

Cytoband

 p11.3

Chromosome location (bp)

 47217860 - 47229997

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102225 (version 83.38)

Entrez gene

 5127

UniProt

 Q00536 (UniProt - Evidence at protein level)

neXtProt

 NX_Q00536

Antibodypedia

 CDK16 antibodies

PROTEIN BROWSER
«
CDK16-001
CDK16-002
CDK16-005
CDK16-007
CDK16-010
CDK16-012
CDK16-015
CDK16-017
CDK16-019
CDK16-021
CDK16-022
CDK16-023
CDK16-201
CDK16-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDK16-001
ENSP00000349762
ENST00000357227
Q00536 [Direct mapping]
Cyclin-dependent kinase 16
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004693 [cyclin-dependent protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006887 [exocytosis]
GO:0007283 [spermatogenesis]
GO:0008021 [synaptic vesicle]
GO:0015630 [microtubule cytoskeleton]
GO:0030054 [cell junction]
GO:0030133 [transport vesicle]
GO:0030252 [growth hormone secretion]
GO:0031175 [neuron projection development]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0043005 [neuron projection]
GO:0051726 [regulation of cell cycle]
GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus]
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 496 aa
55.7 kDa 		No 0
CDK16-002
ENSP00000405798
ENST00000457458
Q00536 [Direct mapping]
Cyclin-dependent kinase 16
A0A024R183 [Target identity:100%; Query identity:100%]
PCTAIRE protein kinase 1, isoform CRA_b
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004693 [cyclin-dependent protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006887 [exocytosis]
GO:0007283 [spermatogenesis]
GO:0008021 [synaptic vesicle]
GO:0015630 [microtubule cytoskeleton]
GO:0030054 [cell junction]
GO:0030133 [transport vesicle]
GO:0030252 [growth hormone secretion]
GO:0031175 [neuron projection development]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0043005 [neuron projection]
GO:0051726 [regulation of cell cycle]
GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus]
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 502 aa
56.4 kDa 		No 0
CDK16-005
ENSP00000429044
ENST00000518391
E5RJM2 [Direct mapping]
Cyclin-dependent kinase 16
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0015630 [microtubule cytoskeleton]
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 189 aa
20.6 kDa 		No 0
CDK16-007
ENSP00000429751
ENST00000518022
Q00536 [Direct mapping]
Cyclin-dependent kinase 16
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004693 [cyclin-dependent protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006887 [exocytosis]
GO:0007283 [spermatogenesis]
GO:0008021 [synaptic vesicle]
GO:0015630 [microtubule cytoskeleton]
GO:0030054 [cell junction]
GO:0030133 [transport vesicle]
GO:0030252 [growth hormone secretion]
GO:0031175 [neuron projection development]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0043005 [neuron projection]
GO:0051726 [regulation of cell cycle]
GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus]
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 496 aa
55.7 kDa 		No 0
CDK16-010
ENSP00000429985
ENST00000517426
E5RGN0 [Direct mapping]
Cyclin-dependent kinase 16
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   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0015630 [microtubule cytoskeleton]
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 393 aa
44.1 kDa 		No 0
CDK16-012
ENSP00000428349
ENST00000523344
H0YAZ9 [Direct mapping]
Cyclin-dependent kinase 16
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
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 260 aa
29.7 kDa 		No 0
CDK16-015
ENSP00000430486
ENST00000523034
H0YBX5 [Direct mapping]
Cyclin-dependent kinase 16
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 152 aa
16.1 kDa 		No 0
CDK16-017
ENSP00000430988
ENST00000520141
H0YC60 [Direct mapping]
Cyclin-dependent kinase 16
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 166 aa
18 kDa 		No 0
CDK16-019
ENSP00000430824
ENST00000462827
H0YC36 [Direct mapping]
Cyclin-dependent kinase 16
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 84 aa
9.1 kDa 		No 0
CDK16-021
ENSP00000431085
ENST00000522883
E5RJQ8 [Direct mapping]
Cyclin-dependent kinase 16
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 57 aa
5.9 kDa 		No 0
CDK16-022
ENSP00000429259
ENST00000519758
E5RIY8 [Direct mapping]
Cyclin-dependent kinase 16
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0015630 [microtubule cytoskeleton]
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 150 aa
16.3 kDa 		No 0
CDK16-023
ENSP00000428351
ENST00000520893
E5RIU4 [Direct mapping]
Cyclin-dependent kinase 16
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0015630 [microtubule cytoskeleton]
Show all
 153 aa
16.6 kDa 		No 0
CDK16-201
ENSP00000276052
ENST00000276052
Q00536 [Direct mapping]
Cyclin-dependent kinase 16
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004693 [cyclin-dependent protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006887 [exocytosis]
GO:0007283 [spermatogenesis]
GO:0008021 [synaptic vesicle]
GO:0015630 [microtubule cytoskeleton]
GO:0030054 [cell junction]
GO:0030133 [transport vesicle]
GO:0030252 [growth hormone secretion]
GO:0031175 [neuron projection development]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0043005 [neuron projection]
GO:0051726 [regulation of cell cycle]
GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus]
Show all
 570 aa
63.5 kDa 		No 0
CDK16-202
ENSP00000482886
ENST00000622098
A0A087WZU2 [Direct mapping]
Cyclin-dependent kinase 16
Show all
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 448 aa
51.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.