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CDK16

GENERAL INFORMATION

Gene name

 CDK16

Gene description

 Cyclin-dependent kinase 16

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 14
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression at variable levels.

DATA RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA001366 , CAB016535
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CDK16 (HGNC Symbol)

Synonyms

 FLJ16665, PCTAIRE, PCTAIRE1, PCTGAIRE, PCTK1

Description

 Cyclin-dependent kinase 16 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2009]

Chromosome

 X

Cytoband

 p11.3

Chromosome location (bp)

 47217860 - 47229997

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102225 (version 83.38)

Entrez gene

 5127

UniProt

 Q00536 (UniProt - Evidence at protein level)

neXtProt

 NX_Q00536

Antibodypedia

 CDK16 antibodies

PROTEIN BROWSER
«
CDK16-001
CDK16-002
CDK16-005
CDK16-007
CDK16-010
CDK16-012
CDK16-015
CDK16-017
CDK16-019
CDK16-021
CDK16-022
CDK16-023
CDK16-201
CDK16-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDK16-001
ENSP00000349762
ENST00000357227
Q00536 [Direct mapping]
Cyclin-dependent kinase 16
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004693 [cyclin-dependent protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006887 [exocytosis]
GO:0007283 [spermatogenesis]
GO:0008021 [synaptic vesicle]
GO:0015630 [microtubule cytoskeleton]
GO:0030054 [cell junction]
GO:0030133 [transport vesicle]
GO:0030252 [growth hormone secretion]
GO:0031175 [neuron projection development]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0043005 [neuron projection]
GO:0051726 [regulation of cell cycle]
GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus]
Show all
 496 aa
55.7 kDa 		No 0
CDK16-002
ENSP00000405798
ENST00000457458
Q00536 [Direct mapping]
Cyclin-dependent kinase 16
A0A024R183 [Target identity:100%; Query identity:100%]
PCTAIRE protein kinase 1, isoform CRA_b
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004693 [cyclin-dependent protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006887 [exocytosis]
GO:0007283 [spermatogenesis]
GO:0008021 [synaptic vesicle]
GO:0015630 [microtubule cytoskeleton]
GO:0030054 [cell junction]
GO:0030133 [transport vesicle]
GO:0030252 [growth hormone secretion]
GO:0031175 [neuron projection development]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0043005 [neuron projection]
GO:0051726 [regulation of cell cycle]
GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus]
Show all
 502 aa
56.4 kDa 		No 0
CDK16-005
ENSP00000429044
ENST00000518391
E5RJM2 [Direct mapping]
Cyclin-dependent kinase 16
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0015630 [microtubule cytoskeleton]
Show all
 189 aa
20.6 kDa 		No 0
CDK16-007
ENSP00000429751
ENST00000518022
Q00536 [Direct mapping]
Cyclin-dependent kinase 16
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004693 [cyclin-dependent protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006887 [exocytosis]
GO:0007283 [spermatogenesis]
GO:0008021 [synaptic vesicle]
GO:0015630 [microtubule cytoskeleton]
GO:0030054 [cell junction]
GO:0030133 [transport vesicle]
GO:0030252 [growth hormone secretion]
GO:0031175 [neuron projection development]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0043005 [neuron projection]
GO:0051726 [regulation of cell cycle]
GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus]
Show all
 496 aa
55.7 kDa 		No 0
CDK16-010
ENSP00000429985
ENST00000517426
E5RGN0 [Direct mapping]
Cyclin-dependent kinase 16
Show all
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0015630 [microtubule cytoskeleton]
Show all
 393 aa
44.1 kDa 		No 0
CDK16-012
ENSP00000428349
ENST00000523344
H0YAZ9 [Direct mapping]
Cyclin-dependent kinase 16
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 260 aa
29.7 kDa 		No 0
CDK16-015
ENSP00000430486
ENST00000523034
H0YBX5 [Direct mapping]
Cyclin-dependent kinase 16
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 152 aa
16.1 kDa 		No 0
CDK16-017
ENSP00000430988
ENST00000520141
H0YC60 [Direct mapping]
Cyclin-dependent kinase 16
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 166 aa
18 kDa 		No 0
CDK16-019
ENSP00000430824
ENST00000462827
H0YC36 [Direct mapping]
Cyclin-dependent kinase 16
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 84 aa
9.1 kDa 		No 0
CDK16-021
ENSP00000431085
ENST00000522883
E5RJQ8 [Direct mapping]
Cyclin-dependent kinase 16
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 57 aa
5.9 kDa 		No 0
CDK16-022
ENSP00000429259
ENST00000519758
E5RIY8 [Direct mapping]
Cyclin-dependent kinase 16
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0015630 [microtubule cytoskeleton]
Show all
 150 aa
16.3 kDa 		No 0
CDK16-023
ENSP00000428351
ENST00000520893
E5RIU4 [Direct mapping]
Cyclin-dependent kinase 16
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0015630 [microtubule cytoskeleton]
Show all
 153 aa
16.6 kDa 		No 0
CDK16-201
ENSP00000276052
ENST00000276052
Q00536 [Direct mapping]
Cyclin-dependent kinase 16
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004693 [cyclin-dependent protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006887 [exocytosis]
GO:0007283 [spermatogenesis]
GO:0008021 [synaptic vesicle]
GO:0015630 [microtubule cytoskeleton]
GO:0030054 [cell junction]
GO:0030133 [transport vesicle]
GO:0030252 [growth hormone secretion]
GO:0031175 [neuron projection development]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0043005 [neuron projection]
GO:0051726 [regulation of cell cycle]
GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus]
Show all
 570 aa
63.5 kDa 		No 0
CDK16-202
ENSP00000482886
ENST00000622098
A0A087WZU2 [Direct mapping]
Cyclin-dependent kinase 16
Show all
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 448 aa
51.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.