Expression of MAGED2 in cancer - Summary - The Human Protein Atlas

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MAGED2

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MAGED2
Gene description	Melanoma antigen family D2
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending retesting.
Reliability score	Supported based on 2 antibodies. HPA031572 , HPA031573
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable), ovarian cancer (favourable) and stomach cancer (unfavourable).
Pancreatic cancer p<0.001 Ovarian cancer p<0.001 Stomach cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA031572	HPA031573

GENE INFORMATION
Gene name	MAGED2 (HGNC Symbol)
Synonyms	11B6, BCG1, HCA10, JCL-1, MAGE-D2, MAGED, MGC8386
Description	Melanoma antigen family D2 (HGNC Symbol)
Entrez gene summary	This gene is a member of the MAGED gene family. The MAGED genes are clustered on chromosome Xp11. This gene is located in Xp11.2, a hot spot for X-linked mental retardation (XLMR). This gene may also be involved in several types of cancer, including breast cancer and melanoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Chromosome	X
Cytoband	p11.21
Chromosome location (bp)	54807599 - 54816012
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000102316 (version 83.38)
Entrez gene	10916
UniProt	Q9UNF1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UNF1
Antibodypedia	MAGED2 antibodies

PROTEIN BROWSER

MAGED2-002	MAGED2-003	MAGED2-004	MAGED2-005	MAGED2-201	MAGED2-202	MAGED2-203	MAGED2-204

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MAGED2-002 ENSP00000364209 ENST00000375068	Q9UNF1 [Direct mapping] Melanoma-associated antigen D2 A0A024R9Y7 [Target identity:100%; Query identity:100%] Melanoma antigen family D, 2, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] Show all	606 aa 65 kDa	No	0
MAGED2-003 ENSP00000364198 ENST00000375058	Q9UNF1 [Direct mapping] Melanoma-associated antigen D2 A0A024R9Y7 [Target identity:100%; Query identity:100%] Melanoma antigen family D, 2, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] Show all	606 aa 65 kDa	No	0
MAGED2-004 ENSP00000336962 ENST00000347546	Q5H909 [Direct mapping] Melanoma-associated antigen D2 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		588 aa 63.1 kDa	No	0
MAGED2-005 ENSP00000364200 ENST00000375060	Q5H907 [Direct mapping] Melanoma antigen family D, 2, isoform CRA_d; Melanoma-associated antigen D2 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		521 aa 55.8 kDa	No	0
MAGED2-201 ENSP00000218439 ENST00000218439	Q9UNF1 [Direct mapping] Melanoma-associated antigen D2 A0A024R9Y7 [Target identity:100%; Query identity:100%] Melanoma antigen family D, 2, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] Show all	606 aa 65 kDa	No	0
MAGED2-202 ENSP00000364193 ENST00000375053	Q9UNF1 [Direct mapping] Melanoma-associated antigen D2 A0A024R9Y7 [Target identity:100%; Query identity:100%] Melanoma antigen family D, 2, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] Show all	606 aa 65 kDa	No	0
MAGED2-203 ENSP00000379526 ENST00000396224	Q9UNF1 [Direct mapping] Melanoma-associated antigen D2 A0A024R9Y7 [Target identity:100%; Query identity:100%] Melanoma antigen family D, 2, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] Show all	606 aa 65 kDa	No	0
MAGED2-204 ENSP00000486563 ENST00000627068	Q5H907 [Direct mapping] Melanoma antigen family D, 2, isoform CRA_d; Melanoma-associated antigen D2 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		521 aa 55.8 kDa	No	0

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The Human Protein Atlas

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