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RBM3

GENERAL INFORMATION

Gene name

 RBM3

Gene description

 RNA binding motif (RNP1, RRM) protein 3

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA003624 , CAB062559
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable).
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA003624
CAB062559

GENE INFORMATION

Gene name

 RBM3 (HGNC Symbol)

Synonyms

 IS1-RNPL

Description

 RNA binding motif (RNP1, RRM) protein 3 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the glycine-rich RNA-binding protein family and encodes a protein with one RNA recognition motif (RRM) domain. Expression of this gene is induced by cold shock and low oxygen tension. A pseudogene exists on chromosome 1. Multiple alternatively spliced transcript variants that are predicted to encode different isoforms have been characterized although some of these variants fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 p11.23

Chromosome location (bp)

 48574449 - 48579066

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102317 (version 83.38)

Entrez gene

 5935

UniProt

 P98179 (UniProt - Evidence at protein level)

neXtProt

 NX_P98179

Antibodypedia

 RBM3 antibodies

PROTEIN BROWSER
RBM3-003
RBM3-004
RBM3-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RBM3-003
ENSP00000365950
ENST00000376759
P98179 [Direct mapping]
RNA-binding protein 3
A0A024QYX3 [Target identity:100%; Query identity:100%]
RNA binding motif (RNP1, RRM) protein 3, isoform CRA_c
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006396 [RNA processing]
GO:0006412 [translation]
GO:0006417 [regulation of translation]
GO:0009409 [response to cold]
GO:0015934 [large ribosomal subunit]
GO:0030425 [dendrite]
GO:0035196 [production of miRNAs involved in gene silencing by miRNA]
GO:0043023 [ribosomal large subunit binding]
GO:0044822 [poly(A) RNA binding]
GO:0045727 [positive regulation of translation]
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 157 aa
17.2 kDa 		No 0
RBM3-004
ENSP00000346473
ENST00000354480
Q9H5V0 [Direct mapping]
RNA binding motif (RNP1, RRM) protein 3, isoform CRA_b; RNA-binding protein 3; cDNA: FLJ23011 fis, clone LNG00572
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   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
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 155 aa
16.7 kDa 		Yes 0
RBM3-005
ENSP00000365946
ENST00000376755
P98179 [Direct mapping]
RNA-binding protein 3
A0A024QYX3 [Target identity:100%; Query identity:100%]
RNA binding motif (RNP1, RRM) protein 3, isoform CRA_c
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006396 [RNA processing]
GO:0006417 [regulation of translation]
GO:0015934 [large ribosomal subunit]
GO:0030425 [dendrite]
GO:0044822 [poly(A) RNA binding]
GO:0045727 [positive regulation of translation]
Show all
 157 aa
17.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.