Moderate to strong nuclear immunoreactivity was observed in basal cell carcinomas along with several melanomas, testicular, breast, head & neck and a few gastric cancers. Remaining cancer tissues were weakly stained or mostly negative.
RBM3 (HGNC Symbol)
RNA binding motif (RNP1, RRM) protein 3 (HGNC Symbol)
Entrez gene summary
This gene is a member of the glycine-rich RNA-binding protein family and encodes a protein with one RNA recognition motif (RRM) domain. Expression of this gene is induced by cold shock and low oxygen tension. A pseudogene exists on chromosome 1. Multiple alternatively spliced transcript variants that are predicted to encode different isoforms have been characterized although some of these variants fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2008]