Expression of BEX4 in cancer - Summary - The Human Protein Atlas

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BEX4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	BEX4
Gene description	Brain expressed, X-linked 4
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HMC-1, K-562)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Uncertain based on 1 antibody. HPA045105
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and pancreatic cancer (favourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA045105

GENE INFORMATION
Gene name	BEX4 (HGNC Symbol)
Synonyms	BEXL1, FLJ10097
Description	Brain expressed, X-linked 4 (HGNC Symbol)
Entrez gene summary	This gene is a member of the brain expressed X-linked gene family. The proteins encoded by some of the other members of this family act as transcription elongation factors which allow RNA polymerase II to escape pausing during elongation. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Aug 2011]
Chromosome	X
Cytoband	q22.1
Chromosome location (bp)	103215092 - 103217246
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000102409 (version 83.38)
Entrez gene	56271
UniProt	Q9NWD9 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9NWD9
Antibodypedia	BEX4 antibodies

PROTEIN BROWSER

BEX4-001	BEX4-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BEX4-001 ENSP00000361780 ENST00000372695	Q9NWD9 [Direct mapping] Protein BEX4 Show all	Predicted intracellular proteins Show all	GO:0005634 [nucleus] GO:0005737 [cytoplasm] Show all	120 aa 14.1 kDa	No	0
BEX4-002 ENSP00000361776 ENST00000372691	Q9NWD9 [Direct mapping] Protein BEX4 Show all	Predicted intracellular proteins Show all	GO:0005634 [nucleus] GO:0005737 [cytoplasm] Show all	120 aa 14.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.