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HTR2A

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GENERAL INFORMATION

Gene name

 HTR2A

Gene description

 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled

Protein class

 FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (ASC TERT1, U-138 MG, U-2 OS, BEWO, HEL)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (ASC TERT1, U-138 MG, U-2 OS, BEWO, HEL)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 HTR2A (HGNC Symbol)

Synonyms

 5-HT2A, HTR2

Description

 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled (HGNC Symbol)

Entrez gene summary

 This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Chromosome

 13

Cytoband

 q14.2

Chromosome location (bp)

 46831550 - 46897076

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102468 (version 83.38)

Entrez gene

 3356

UniProt

 P28223 (UniProt - Evidence at protein level)

neXtProt

 NX_P28223

Antibodypedia

 HTR2A antibodies

PROTEIN BROWSER
HTR2A-001
HTR2A-002
HTR2A-201
HTR2A-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HTR2A-001
ENSP00000367959
ENST00000378688
P28223 [Direct mapping]
5-hydroxytryptamine receptor 2A
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Serotonin receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001618 [virus receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0004993 [serotonin receptor activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005901 [caveola]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007210 [serotonin receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0008144 [drug binding]
GO:0010513 [positive regulation of phosphatidylinositol biosynthetic process]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030424 [axon]
GO:0042493 [response to drug]
GO:0046718 [viral entry into host cell]
GO:0046883 [regulation of hormone secretion]
GO:0050795 [regulation of behavior]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0051378 [serotonin binding]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071886 [1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding]
Show all
 471 aa
52.6 kDa 		No 7
HTR2A-002
ENSP00000482708
ENST00000612998
A0A087WZJ9 [Direct mapping]
5-hydroxytryptamine receptor 2A
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004993 [serotonin receptor activity]
GO:0005887 [integral component of plasma membrane]
GO:0006939 [smooth muscle contraction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007210 [serotonin receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0043198 [dendritic shaft]
GO:0046883 [regulation of hormone secretion]
GO:0050795 [regulation of behavior]
Show all
 110 aa
12.1 kDa 		No 2
HTR2A-201
ENSP00000437737
ENST00000542664
P28223 [Direct mapping]
5-hydroxytryptamine receptor 2A
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Serotonin receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0001659 [temperature homeostasis]
GO:0001965 [G-protein alpha-subunit binding]
GO:0004930 [G-protein coupled receptor activity]
GO:0004993 [serotonin receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005901 [caveola]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007208 [phospholipase C-activating serotonin receptor signaling pathway]
GO:0007210 [serotonin receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007568 [aging]
GO:0007613 [memory]
GO:0008144 [drug binding]
GO:0008219 [cell death]
GO:0008284 [positive regulation of cell proliferation]
GO:0010513 [positive regulation of phosphatidylinositol biosynthetic process]
GO:0014059 [regulation of dopamine secretion]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0014824 [artery smooth muscle contraction]
GO:0014832 [urinary bladder smooth muscle contraction]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0019233 [sensory perception of pain]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030431 [sleep]
GO:0032403 [protein complex binding]
GO:0033674 [positive regulation of kinase activity]
GO:0042493 [response to drug]
GO:0043025 [neuronal cell body]
GO:0043198 [dendritic shaft]
GO:0043267 [negative regulation of potassium ion transport]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0044380 [protein localization to cytoskeleton]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045821 [positive regulation of glycolytic process]
GO:0045907 [positive regulation of vasoconstriction]
GO:0046718 [viral entry into host cell]
GO:0046883 [regulation of hormone secretion]
GO:0048148 [behavioral response to cocaine]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050795 [regulation of behavior]
GO:0050965 [detection of temperature stimulus involved in sensory perception of pain]
GO:0050966 [detection of mechanical stimulus involved in sensory perception of pain]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0051378 [serotonin binding]
GO:0051967 [negative regulation of synaptic transmission, glutamatergic]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070852 [cell body fiber]
GO:0071886 [1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding]
Show all
 471 aa
52.6 kDa 		No 7
HTR2A-202
ENSP00000441861
ENST00000543956
P28223 [Direct mapping]
5-hydroxytryptamine receptor 2A
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Serotonin receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0004993 [serotonin receptor activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005901 [caveola]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007210 [serotonin receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0008144 [drug binding]
GO:0010513 [positive regulation of phosphatidylinositol biosynthetic process]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030424 [axon]
GO:0042493 [response to drug]
GO:0046718 [viral entry into host cell]
GO:0046883 [regulation of hormone secretion]
GO:0050795 [regulation of behavior]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0051378 [serotonin binding]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071886 [1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding]
Show all
 387 aa
43.9 kDa 		No 5

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.