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Few skin and urothelial cancers showed weak to moderate cytoplasmic immunoreactivity. A single case of pancreatic cancer exhibited strong cytoplasmic positivity with a granular patter. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
HTR2A (HGNC Symbol)
Synonyms
5-HT2A, HTR2
Description
5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled (HGNC Symbol)
Entrez gene summary
This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]