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SGCG

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GENERAL INFORMATION

Gene name

 SGCG

Gene description

 Sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)

Protein class

 Disease related genes
Plasma proteins
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Cell line enhanced (U-87 MG, EFO-21, AF22)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported)

DATA RELIABILITY

Reliability score

 Supported based on 2 antibodies.
HPA007476 , HPA011922
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-87 MG, EFO-21, AF22)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA011922 A-431 Nucleoplasm
HPA011922 U-2 OS No staining    
HPA011922 U-251 MG No staining    
HPA007476 A-431 No staining    
HPA007476 U-2 OS No staining    
HPA007476 U-251 MG Nucleoplasm

GENE INFORMATION

Gene name

 SGCG (HGNC Symbol)

Synonyms

 A4, DAGA4, DMDA, DMDA1, LGMD2C, MAM, MGC130048, SCARMD2, SCG3, TYPE

Description

 Sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) (HGNC Symbol)

Entrez gene summary

 This gene encodes gamma-sarcoglycan, one of several sarcolemmal transmembrane glycoproteins that interact with dystrophin. The dystrophin-glycoprotein complex (DGC) spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Defects in the encoded protein can lead to early onset autosomal recessive muscular dystrophy, in particular limb-girdle muscular dystrophy, type 2C (LGMD2C). [provided by RefSeq, Oct 2008]

Chromosome

 13

Cytoband

 q12.12

Chromosome location (bp)

 23180952 - 23325165

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102683 (version 83.38)

Entrez gene

 6445

UniProt

 Q13326 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13326

Antibodypedia

 SGCG antibodies

PROTEIN BROWSER
SGCG-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SGCG-001
ENSP00000218867
ENST00000218867
Q13326 [Direct mapping]
Gamma-sarcoglycan
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0007517 [muscle organ development]
GO:0016011 [dystroglycan complex]
GO:0016012 [sarcoglycan complex]
GO:0016021 [integral component of membrane]
GO:0042383 [sarcolemma]
GO:0048738 [cardiac muscle tissue development]
GO:0055001 [muscle cell development]
GO:0060047 [heart contraction]
GO:0061024 [membrane organization]
Show all
 291 aa
32.4 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.