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PARP4

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GENERAL INFORMATION

Gene name

 PARP4

Gene description

 Poly (ADP-ribose) polymerase family, member 4

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA011739
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol.

Main location

 Cytosol (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA011739 A-431 Cytosol
HPA011739 U-2 OS Cytosol
HPA011739 U-251 MG Cytosol

GENE INFORMATION

Gene name

 PARP4 (HGNC Symbol)

Synonyms

 ADPRTL1, p193, VAULT3, VPARP, VWA5C

Description

 Poly (ADP-ribose) polymerase family, member 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. [provided by RefSeq, Jul 2008]

Chromosome

 13

Cytoband

 q12.12

Chromosome location (bp)

 24420926 - 24512810

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102699 (version 83.38)

Entrez gene

 143

UniProt

 Q9UKK3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UKK3

Antibodypedia

 PARP4 antibodies

PROTEIN BROWSER
PARP4-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PARP4-001
ENSP00000371419
ENST00000381989
Q9UKK3 [Direct mapping]
Poly [ADP-ribose] polymerase 4
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Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003950 [NAD+ ADP-ribosyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005876 [spindle microtubule]
GO:0006281 [DNA repair]
GO:0006464 [cellular protein modification process]
GO:0006471 [protein ADP-ribosylation]
GO:0006810 [transport]
GO:0006954 [inflammatory response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008219 [cell death]
GO:0016020 [membrane]
GO:0019899 [enzyme binding]
GO:0030529 [ribonucleoprotein complex]
GO:0042493 [response to drug]
GO:0070062 [extracellular exosome]
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 1724 aa
192.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.