Expression of PARP4 in cancer - Summary

GENERAL INFORMATION
Gene name	PARP4
Gene description	Poly (ADP-ribose) polymerase family, member 4
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression, additional expression in lymphoid cells in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA011739
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA011739

GENE INFORMATION
Gene name	PARP4 (HGNC Symbol)
Synonyms	ADPRTL1, p193, VAULT3, VPARP, VWA5C
Description	Poly (ADP-ribose) polymerase family, member 4 (HGNC Symbol)
Entrez gene summary	This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. [provided by RefSeq, Jul 2008]
Chromosome	13
Cytoband	q12.12
Chromosome location (bp)	24420926 - 24512810
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000102699 (version 83.38)
Entrez gene	143
UniProt	Q9UKK3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UKK3
Antibodypedia	PARP4 antibodies

PROTEIN BROWSER

PARP4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PARP4-001 ENSP00000371419 ENST00000381989	Q9UKK3 [Direct mapping] Poly [ADP-ribose] polymerase 4 Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003950 [NAD+ ADP-ribosyltransferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005876 [spindle microtubule] GO:0006281 [DNA repair] GO:0006464 [cellular protein modification process] GO:0006471 [protein ADP-ribosylation] GO:0006810 [transport] GO:0006954 [inflammatory response] GO:0006974 [cellular response to DNA damage stimulus] GO:0008219 [cell death] GO:0016020 [membrane] GO:0019899 [enzyme binding] GO:0030529 [ribonucleoprotein complex] GO:0042493 [response to drug] GO:0070062 [extracellular exosome] Show all	1724 aa 192.6 kDa	No	0