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RGCC

GENERAL INFORMATION

Gene name

 RGCC

Gene description

 Regulator of cell cycle

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (BJ hTERT+, Daudi, U-698)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic and membranous expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA035638
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (unfavourable).
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA035638

GENE INFORMATION

Gene name

 RGCC (HGNC Symbol)

Synonyms

 bA157L14.2, C13orf15, RGC-32, RGC32

Description

 Regulator of cell cycle (HGNC Symbol)

Entrez gene summary

 This gene is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic levels of complement system proteins that result in activation of the cell cycle. The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex with polo-like kinase 1. The protein also translocates to the nucleus in response to treatment with complement system proteins, and can associate with and increase the kinase activity of cell division cycle 2 protein. In different assays and cell types, overexpression of this protein has been shown to activate or suppress cell cycle progression. [provided by RefSeq, Jul 2008]

Chromosome

 13

Cytoband

 q14.11

Chromosome location (bp)

 41457559 - 41470882

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102760 (version 83.38)

Entrez gene

 28984

UniProt

 Q9H4X1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H4X1

Antibodypedia

 RGCC antibodies

PROTEIN BROWSER
RGCC-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RGCC-001
ENSP00000368664
ENST00000379359
Q9H4X1 [Direct mapping]
Regulator of cell cycle RGCC
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001100 [negative regulation of exit from mitosis]
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0003331 [positive regulation of extracellular matrix constituent secretion]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006956 [complement activation]
GO:0008285 [negative regulation of cell proliferation]
GO:0010628 [positive regulation of gene expression]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0016525 [negative regulation of angiogenesis]
GO:0019901 [protein kinase binding]
GO:0030295 [protein kinase activator activity]
GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle]
GO:0032147 [activation of protein kinase activity]
GO:0032967 [positive regulation of collagen biosynthetic process]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050710 [negative regulation of cytokine secretion]
GO:0050715 [positive regulation of cytokine secretion]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051726 [regulation of cell cycle]
GO:0070412 [R-SMAD binding]
GO:0071158 [positive regulation of cell cycle arrest]
GO:0071456 [cellular response to hypoxia]
GO:0071850 [mitotic cell cycle arrest]
GO:0072537 [fibroblast activation]
GO:0090272 [negative regulation of fibroblast growth factor production]
GO:1901203 [positive regulation of extracellular matrix assembly]
GO:1901991 [negative regulation of mitotic cell cycle phase transition]
GO:2000048 [negative regulation of cell-cell adhesion mediated by cadherin]
GO:2000353 [positive regulation of endothelial cell apoptotic process]
GO:2000573 [positive regulation of DNA biosynthetic process]
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 137 aa
14.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.