Cell atlas - MLYCD - The Human Protein Atlas

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MLYCD

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	MLYCD
Gene description	Malonyl-CoA decarboxylase
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	MLYCD (HGNC Symbol)
Synonyms	hMCD, MCD
Description	Malonyl-CoA decarboxylase (HGNC Symbol)
Entrez gene summary	The product of this gene catalyzes the breakdown of malonyl-CoA to acetyl-CoA and carbon dioxide. Malonyl-CoA is an intermediate in fatty acid biosynthesis, and also inhibits the transport of fatty acyl CoAs into mitochondria. Consequently, the encoded protein acts to increase the rate of fatty acid oxidation. It is found in mitochondria, peroxisomes, and the cytoplasm. Mutations in this gene result in malonyl-CoA decarboyxlase deficiency. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	q23.3
Chromosome location (bp)	83899126 - 83927026
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000103150 (version 83.38)
Entrez gene	23417
UniProt	O95822 (UniProt - Evidence at protein level)
neXtProt	NX_O95822
Antibodypedia	MLYCD antibodies

PROTEIN BROWSER

MLYCD-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MLYCD-001 ENSP00000262430 ENST00000262430	O95822 [Direct mapping] Malonyl-CoA decarboxylase, mitochondrial Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002931 [response to ischemia] GO:0005102 [receptor binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005777 [peroxisome] GO:0005782 [peroxisomal matrix] GO:0006085 [acetyl-CoA biosynthetic process] GO:0006633 [fatty acid biosynthetic process] GO:0010906 [regulation of glucose metabolic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0046321 [positive regulation of fatty acid oxidation] GO:0050080 [malonyl-CoA decarboxylase activity] GO:2001294 [malonyl-CoA catabolic process] Show all	493 aa 55 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.