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MLYCD

GENERAL INFORMATION

Gene name

 MLYCD

Gene description

 Malonyl-CoA decarboxylase

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression, often with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA031625
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA031625

GENE INFORMATION

Gene name

 MLYCD (HGNC Symbol)

Synonyms

 hMCD, MCD

Description

 Malonyl-CoA decarboxylase (HGNC Symbol)

Entrez gene summary

 The product of this gene catalyzes the breakdown of malonyl-CoA to acetyl-CoA and carbon dioxide. Malonyl-CoA is an intermediate in fatty acid biosynthesis, and also inhibits the transport of fatty acyl CoAs into mitochondria. Consequently, the encoded protein acts to increase the rate of fatty acid oxidation. It is found in mitochondria, peroxisomes, and the cytoplasm. Mutations in this gene result in malonyl-CoA decarboyxlase deficiency. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 q23.3

Chromosome location (bp)

 83899126 - 83927026

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000103150 (version 83.38)

Entrez gene

 23417

UniProt

 O95822 (UniProt - Evidence at protein level)

neXtProt

 NX_O95822

Antibodypedia

 MLYCD antibodies

PROTEIN BROWSER
MLYCD-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MLYCD-001
ENSP00000262430
ENST00000262430
O95822 [Direct mapping]
Malonyl-CoA decarboxylase, mitochondrial
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Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002931 [response to ischemia]
GO:0005102 [receptor binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005777 [peroxisome]
GO:0005782 [peroxisomal matrix]
GO:0006085 [acetyl-CoA biosynthetic process]
GO:0006633 [fatty acid biosynthetic process]
GO:0010906 [regulation of glucose metabolic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046321 [positive regulation of fatty acid oxidation]
GO:0050080 [malonyl-CoA decarboxylase activity]
GO:2001294 [malonyl-CoA catabolic process]
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 493 aa
55 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.