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CAPN15

GENERAL INFORMATION

Gene name

 CAPN15

Gene description

 Calpain 15

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 High cytoplasmic expression in a few tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA011960
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA011960

GENE INFORMATION

Gene name

 CAPN15 (HGNC Symbol)

Synonyms

 SOLH

Description

 Calpain 15 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein containing zinc-finger-like repeats and a calpain-like protease domain. The encoded protein may function as a transcription factor, RNA-binding protein, or in protein-protein interactions during visual system development. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 p13.3

Chromosome location (bp)

 527717 - 554636

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000103326 (version 83.38)

Entrez gene

 6650

UniProt

 O75808 (UniProt - Evidence at protein level)

neXtProt

 NX_O75808

Antibodypedia

 CAPN15 antibodies

PROTEIN BROWSER
CAPN15-001
CAPN15-005
CAPN15-006
CAPN15-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CAPN15-001
ENSP00000219611
ENST00000219611
O75808 [Direct mapping]
Calpain-15
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Enzymes
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006508 [proteolysis]
GO:0008233 [peptidase activity]
GO:0008234 [cysteine-type peptidase activity]
GO:0008270 [zinc ion binding]
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 1086 aa
117.3 kDa 		No 0
CAPN15-005
ENSP00000456017
ENST00000562370
H3BR03 [Direct mapping]
Calpain-15
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
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 185 aa
19.9 kDa 		No 0
CAPN15-006
ENSP00000457030
ENST00000568988
H3BT55 [Direct mapping]
Calpain-15
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
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 112 aa
11.9 kDa 		No 0
CAPN15-008
ENSP00000457306
ENST00000566977
H3BTS4 [Direct mapping]
Calpain-15
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
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 71 aa
7.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.