Cell atlas - CDIPT - The Human Protein Atlas

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CDIPT

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear membrane
	Nucleoplasm
	Plasma membrane

Human cell
	Nuclear membrane
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	CDIPT
Gene description	CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear membrane, plasma membrane & nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Nuclear membrane (approved), Plasma membrane (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA056597
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear membrane, plasma membrane & nucleoplasm.

Main location

Nucleoplasm (approved), Nuclear membrane (approved), Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA056597	A549	Nucleoplasm
			Nuclear membrane
			Plasma membrane
	HPA056597	MCF7	No staining

GENE INFORMATION
Gene name	CDIPT (HGNC Symbol)
Synonyms	PIS, PIS1
Description	CDP-diacylglycerol--inositol 3-phosphatidyltransferase (HGNC Symbol)
Entrez gene summary	Phosphatidylinositol breakdown products are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. Two enzymes, CDP-diacylglycerol synthase and phosphatidylinositol synthase, are involved in the biosynthesis of phosphatidylinositol. Phosphatidylinositol synthase, a member of the CDP-alcohol phosphatidyl transferase class-I family, is an integral membrane protein found on the cytoplasmic side of the endoplasmic reticulum and the Golgi apparatus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Chromosome	16
Cytoband	p11.2
Chromosome location (bp)	29858357 - 29863736
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000103502 (version 83.38)
Entrez gene	10423
UniProt	O14735 (UniProt - Evidence at protein level)
neXtProt	NX_O14735
Antibodypedia	CDIPT antibodies

PROTEIN BROWSER

CDIPT-001	CDIPT-003	CDIPT-004	CDIPT-005	CDIPT-007	CDIPT-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDIPT-001 ENSP00000219789 ENST00000219789	O14735 [Direct mapping] CDP-diacylglycerol--inositol 3-phosphatidyltransferase A8K3L7 [Target identity:100%; Query identity:100%] CDP-diacylglycerol--inositol 3-phosphatidyltransferase (Phosphatidylinositol synthase), isoform CRA_a; cDNA FLJ40372 fis, clone TESTI2034940, highly similar to CDP-diacylglycerol--inositol3-phosphatidyltransferase (EC 2.7.8.11); cDNA FLJ77674, highly similar to Homo sapiens CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) (CDIPT), transcript variant 1, mRNA Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003881 [CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006644 [phospholipid metabolic process] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0008654 [phospholipid biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016780 [phosphotransferase activity, for other substituted phosphate groups] GO:0019992 [diacylglycerol binding] GO:0030145 [manganese ion binding] GO:0030246 [carbohydrate binding] GO:0043178 [alcohol binding] GO:0044281 [small molecule metabolic process] GO:0046341 [CDP-diacylglycerol metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] Show all	213 aa 23.5 kDa	No	5
CDIPT-003 ENSP00000457340 ENST00000566113	O14735 [Direct mapping] CDP-diacylglycerol--inositol 3-phosphatidyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003881 [CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006644 [phospholipid metabolic process] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] Show all	168 aa 18.6 kDa	No	3
CDIPT-004 ENSP00000454453 ENST00000570016	O14735 [Direct mapping] CDP-diacylglycerol--inositol 3-phosphatidyltransferase A8K3L7 [Target identity:100%; Query identity:100%] CDP-diacylglycerol--inositol 3-phosphatidyltransferase (Phosphatidylinositol synthase), isoform CRA_a; cDNA FLJ40372 fis, clone TESTI2034940, highly similar to CDP-diacylglycerol--inositol3-phosphatidyltransferase (EC 2.7.8.11); cDNA FLJ77674, highly similar to Homo sapiens CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) (CDIPT), transcript variant 1, mRNA Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003881 [CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006644 [phospholipid metabolic process] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0008654 [phospholipid biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016780 [phosphotransferase activity, for other substituted phosphate groups] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] Show all	213 aa 23.5 kDa	No	5
CDIPT-005 ENSP00000455042 ENST00000561555	B3KY94 [Direct mapping] CDP-diacylglycerol--inositol 3-phosphatidyltransferase; cDNA FLJ16129 fis, clone BRACE2039823, highly similar to CDP-diacylglycerol--inositol3-phosphatidyltransferase (EC 2.7.8.11) Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005794 [Golgi apparatus] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016740 [transferase activity] Show all	237 aa 25.9 kDa	Yes	3
CDIPT-007 ENSP00000457339 ENST00000569956	O14735 [Direct mapping] CDP-diacylglycerol--inositol 3-phosphatidyltransferase A8K3L7 [Target identity:100%; Query identity:100%] CDP-diacylglycerol--inositol 3-phosphatidyltransferase (Phosphatidylinositol synthase), isoform CRA_a; cDNA FLJ40372 fis, clone TESTI2034940, highly similar to CDP-diacylglycerol--inositol3-phosphatidyltransferase (EC 2.7.8.11); cDNA FLJ77674, highly similar to Homo sapiens CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) (CDIPT), transcript variant 1, mRNA Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003881 [CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006644 [phospholipid metabolic process] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0008654 [phospholipid biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016780 [phosphotransferase activity, for other substituted phosphate groups] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] Show all	213 aa 23.5 kDa	No	5
CDIPT-009 ENSP00000457766 ENST00000563415	H3BUR9 [Direct mapping] CDP-diacylglycerol--inositol 3-phosphatidyltransferase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005794 [Golgi apparatus] GO:0008654 [phospholipid biosynthetic process] GO:0016020 [membrane] GO:0016780 [phosphotransferase activity, for other substituted phosphate groups] Show all	157 aa 17.3 kDa	No	3

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.