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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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CSK
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

CSK

Gene description

C-src tyrosine kinase

Protein class

Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues, including subsets of immune cells.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 3 antibodies.
HPA026488 , HPA028425 , CAB011203
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Appendix

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

CSK

Synonyms

Description

C-src tyrosine kinase (HGNC Symbol)

Entrez gene summary

Chromosome

15

Cytoband

q24.1

Chromosome location (bp)

74782057 - 74803198

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000103653 (version 83.38)

Entrez gene

1445

UniProt

P41240 (UniProt - Evidence at protein level)

neXtProt

NX_P41240

Antibodypedia

CSK antibodies

PROTEIN BROWSER

CSK-001
CSK-002
CSK-006
CSK-008
CSK-015
CSK-016

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CSK-001
ENSP00000220003
ENST00000220003
P41240 [Direct mapping]
Tyrosine-protein kinase CSK
B2R6Q4 [Target identity:100%; Query identity:100%]
Non-specific protein-tyrosine kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001817 [regulation of cytokine production]
GO:0002009 [morphogenesis of an epithelium]
GO:0002250 [adaptive immune response]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007420 [brain development]
GO:0007596 [blood coagulation]
GO:0008022 [protein C-terminus binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0010989 [negative regulation of low-density lipoprotein particle clearance]
GO:0016477 [cell migration]
GO:0019903 [protein phosphatase binding]
GO:0030154 [cell differentiation]
GO:0030168 [platelet activation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0032715 [negative regulation of interleukin-6 production]
GO:0033673 [negative regulation of kinase activity]
GO:0034236 [protein kinase A catalytic subunit binding]
GO:0034332 [adherens junction organization]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0042802 [identical protein binding]
GO:0042997 [negative regulation of Golgi to plasma membrane protein transport]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045779 [negative regulation of bone resorption]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0048709 [oligodendrocyte differentiation]
GO:0050765 [negative regulation of phagocytosis]
GO:0050852 [T cell receptor signaling pathway]
GO:0060368 [regulation of Fc receptor mediated stimulatory signaling pathway]
GO:0070062 [extracellular exosome]
GO:0070064 [proline-rich region binding]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0071375 [cellular response to peptide hormone stimulus]
Show all
450 aa
50.7 kDa
No 0
CSK-002
ENSP00000414764
ENST00000439220
P41240 [Direct mapping]
Tyrosine-protein kinase CSK
B2R6Q4 [Target identity:100%; Query identity:100%]
Non-specific protein-tyrosine kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001817 [regulation of cytokine production]
GO:0002009 [morphogenesis of an epithelium]
GO:0002250 [adaptive immune response]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0008022 [protein C-terminus binding]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0030168 [platelet activation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0034236 [protein kinase A catalytic subunit binding]
GO:0034332 [adherens junction organization]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0042802 [identical protein binding]
GO:0042997 [negative regulation of Golgi to plasma membrane protein transport]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0050852 [T cell receptor signaling pathway]
GO:0060368 [regulation of Fc receptor mediated stimulatory signaling pathway]
GO:0070062 [extracellular exosome]
Show all
450 aa
50.7 kDa
No 0
CSK-006
ENSP00000454906
ENST00000567571
P41240 [Direct mapping]
Tyrosine-protein kinase CSK
B2R6Q4 [Target identity:100%; Query identity:100%]
Non-specific protein-tyrosine kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001817 [regulation of cytokine production]
GO:0002009 [morphogenesis of an epithelium]
GO:0002250 [adaptive immune response]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0008022 [protein C-terminus binding]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0030168 [platelet activation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0034236 [protein kinase A catalytic subunit binding]
GO:0034332 [adherens junction organization]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0042802 [identical protein binding]
GO:0042997 [negative regulation of Golgi to plasma membrane protein transport]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0050852 [T cell receptor signaling pathway]
GO:0060368 [regulation of Fc receptor mediated stimulatory signaling pathway]
GO:0070062 [extracellular exosome]
Show all
450 aa
50.7 kDa
No 0
CSK-008
ENSP00000454640
ENST00000569915
H3BN15 [Direct mapping]
Tyrosine-protein kinase CSK
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001817 [regulation of cytokine production]
GO:0002009 [morphogenesis of an epithelium]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0034332 [adherens junction organization]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
GO:0060368 [regulation of Fc receptor mediated stimulatory signaling pathway]
Show all
65 aa
7.1 kDa
No 0
CSK-015
ENSP00000457497
ENST00000567123
H3BU69 [Direct mapping]
Tyrosine-protein kinase CSK
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001817 [regulation of cytokine production]
GO:0002009 [morphogenesis of an epithelium]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0034332 [adherens junction organization]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
GO:0060368 [regulation of Fc receptor mediated stimulatory signaling pathway]
Show all
68 aa
8.1 kDa
No 0
CSK-016
ENSP00000457714
ENST00000569462
H3BUM9 [Direct mapping]
Tyrosine-protein kinase CSK
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001817 [regulation of cytokine production]
GO:0002009 [morphogenesis of an epithelium]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0034332 [adherens junction organization]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
GO:0060368 [regulation of Fc receptor mediated stimulatory signaling pathway]
Show all
110 aa
12.3 kDa
No 0

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.