Expression of IGDCC4 in cancer - Summary - The Human Protein Atlas

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IGDCC4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	IGDCC4
Gene description	Immunoglobulin superfamily, DCC subclass, member 4
Protein class	Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (glioma)
HPA (cell line):	Cell line enhanced (AF22, CAPAN-2, NTERA-2)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression at variable levels in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA008576
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (glioma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA008576

GENE INFORMATION
Gene name	IGDCC4 (HGNC Symbol)
Synonyms	LOC57722, NOPE
Description	Immunoglobulin superfamily, DCC subclass, member 4 (HGNC Symbol)
Entrez gene summary
Chromosome	15
Cytoband	q22.31
Chromosome location (bp)	65381464 - 65423072
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000103742 (version 83.38)
Entrez gene	57722
UniProt	Q8TDY8 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TDY8
Antibodypedia	IGDCC4 antibodies

PROTEIN BROWSER

IGDCC4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IGDCC4-001 ENSP00000319623 ENST00000352385	Q8TDY8 [Direct mapping] Immunoglobulin superfamily DCC subclass member 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] Show all	1250 aa 134.2 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.