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FZD3

GENERAL INFORMATION

Gene name

 FZD3

Gene description

 Frizzled class receptor 3

Protein class

 G-protein coupled receptors
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (AF22, SCLC-21H)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB024995
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable) and ovarian cancer (favourable).
Colorectal cancer p<0.001
Ovarian cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB024995

GENE INFORMATION

Gene name

 FZD3

Synonyms

Description

 Frizzled class receptor 3 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development. Alternative splicing results in multiple transcript variants. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010]

Chromosome

 8

Cytoband

 p21.1

Chromosome location (bp)

 28494205 - 28574268

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104290 (version 83.38)

Entrez gene

 7976

UniProt

 Q9NPG1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NPG1

Antibodypedia

 FZD3 antibodies

PROTEIN BROWSER
FZD3-001
FZD3-002
FZD3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FZD3-001
ENSP00000240093
ENST00000240093
Q9NPG1 [Direct mapping]
Frizzled-3
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G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family fz/smo receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002052 [positive regulation of neuroblast proliferation]
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0017147 [Wnt-protein binding]
GO:0030165 [PDZ domain binding]
GO:0030182 [neuron differentiation]
GO:0035567 [non-canonical Wnt signaling pathway]
GO:0042813 [Wnt-activated receptor activity]
GO:0045976 [negative regulation of mitotic cell cycle, embryonic]
GO:0060070 [canonical Wnt signaling pathway]
GO:0061549 [sympathetic ganglion development]
GO:1900118 [negative regulation of execution phase of apoptosis]
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 666 aa
76.3 kDa 		Yes 7
FZD3-002
ENSP00000430125
ENST00000523546
E5RGI9 [Direct mapping]
Frizzled-3
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   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0035567 [non-canonical Wnt signaling pathway]
GO:0042813 [Wnt-activated receptor activity]
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 35 aa
4 kDa 		No 0
FZD3-201
ENSP00000437489
ENST00000537916
Q9NPG1 [Direct mapping]
Frizzled-3
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G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family fz/smo receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001736 [establishment of planar polarity]
GO:0001764 [neuron migration]
GO:0001843 [neural tube closure]
GO:0001942 [hair follicle development]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0017147 [Wnt-protein binding]
GO:0030165 [PDZ domain binding]
GO:0030182 [neuron differentiation]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030901 [midbrain development]
GO:0032433 [filopodium tip]
GO:0033278 [cell proliferation in midbrain]
GO:0035567 [non-canonical Wnt signaling pathway]
GO:0036342 [post-anal tail morphogenesis]
GO:0042472 [inner ear morphogenesis]
GO:0042813 [Wnt-activated receptor activity]
GO:0043025 [neuronal cell body]
GO:0045177 [apical part of cell]
GO:0045976 [negative regulation of mitotic cell cycle, embryonic]
GO:0048786 [presynaptic active zone]
GO:0060070 [canonical Wnt signaling pathway]
GO:0061549 [sympathetic ganglion development]
GO:0071679 [commissural neuron axon guidance]
GO:1900118 [negative regulation of execution phase of apoptosis]
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 666 aa
76.3 kDa 		Yes 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.