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FZD3

GENERAL INFORMATION

Gene name

 FZD3

Gene description

 Frizzled class receptor 3

Protein class

 G-protein coupled receptors
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB024995
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 FZD3

Synonyms

Description

 Frizzled class receptor 3 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development. Alternative splicing results in multiple transcript variants. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010]

Chromosome

 8

Cytoband

 p21.1

Chromosome location (bp)

 28494205 - 28574268

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104290 (version 83.38)

Entrez gene

 7976

UniProt

 Q9NPG1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NPG1

Antibodypedia

 FZD3 antibodies

PROTEIN BROWSER
FZD3-001
FZD3-002
FZD3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FZD3-001
ENSP00000240093
ENST00000240093
Q9NPG1 [Direct mapping]
Frizzled-3
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G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family fz/smo receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0017147 [Wnt-protein binding]
GO:0030165 [PDZ domain binding]
GO:0030182 [neuron differentiation]
GO:0035567 [non-canonical Wnt signaling pathway]
GO:0042813 [Wnt-activated receptor activity]
GO:0045976 [negative regulation of mitotic cell cycle, embryonic]
GO:0060070 [canonical Wnt signaling pathway]
GO:0061549 [sympathetic ganglion development]
GO:1900118 [negative regulation of execution phase of apoptosis]
Show all
 666 aa
76.3 kDa 		Yes 7
FZD3-002
ENSP00000430125
ENST00000523546
E5RGI9 [Direct mapping]
Frizzled-3
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   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0035567 [non-canonical Wnt signaling pathway]
GO:0042813 [Wnt-activated receptor activity]
Show all
 35 aa
4 kDa 		No 0
FZD3-201
ENSP00000437489
ENST00000537916
Q9NPG1 [Direct mapping]
Frizzled-3
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family fz/smo receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001736 [establishment of planar polarity]
GO:0001764 [neuron migration]
GO:0001843 [neural tube closure]
GO:0001942 [hair follicle development]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0017147 [Wnt-protein binding]
GO:0030165 [PDZ domain binding]
GO:0030182 [neuron differentiation]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030901 [midbrain development]
GO:0032433 [filopodium tip]
GO:0033278 [cell proliferation in midbrain]
GO:0035567 [non-canonical Wnt signaling pathway]
GO:0036342 [post-anal tail morphogenesis]
GO:0042472 [inner ear morphogenesis]
GO:0042813 [Wnt-activated receptor activity]
GO:0043025 [neuronal cell body]
GO:0045177 [apical part of cell]
GO:0045976 [negative regulation of mitotic cell cycle, embryonic]
GO:0048786 [presynaptic active zone]
GO:0060070 [canonical Wnt signaling pathway]
GO:0061549 [sympathetic ganglion development]
GO:0071679 [commissural neuron axon guidance]
GO:1900118 [negative regulation of execution phase of apoptosis]
Show all
 666 aa
76.3 kDa 		Yes 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.