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EIF3E

GENERAL INFORMATION

Gene name

 EIF3E

Gene description

 Eukaryotic translation initiation factor 3, subunit E

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA023973
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Urothelial cancer

STAINING SUMMARY
HPA023973

GENE INFORMATION

Gene name

 EIF3E (HGNC Symbol)

Synonyms

 eIF3-p48, eIF3e, EIF3S6, INT6

Description

 Eukaryotic translation initiation factor 3, subunit E (HGNC Symbol)

Entrez gene summary

Chromosome

 8

Cytoband

 q23.1

Chromosome location (bp)

 108201216 - 108435333

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104408 (version 83.38)

Entrez gene

 3646

UniProt

 P60228 (UniProt - Evidence at protein level)

neXtProt

 NX_P60228

Antibodypedia

 EIF3E antibodies

PROTEIN BROWSER
EIF3E-001
EIF3E-002
EIF3E-007
EIF3E-008
EIF3E-010
EIF3E-011
EIF3E-015

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EIF3E-001
ENSP00000220849
ENST00000220849
P60228 [Direct mapping]
Eukaryotic translation initiation factor 3 subunit E
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0000785 [chromatin]
GO:0001731 [formation of translation preinitiation complex]
GO:0003743 [translation initiation factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005852 [eukaryotic translation initiation factor 3 complex]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006446 [regulation of translational initiation]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016282 [eukaryotic 43S preinitiation complex]
GO:0016605 [PML body]
GO:0033290 [eukaryotic 48S preinitiation complex]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045947 [negative regulation of translational initiation]
GO:0047485 [protein N-terminus binding]
GO:0070062 [extracellular exosome]
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 445 aa
52.2 kDa 		No 0
EIF3E-002
ENSP00000428796
ENST00000519030
E5RGA2 [Direct mapping]
Eukaryotic translation initiation factor 3 subunit E
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001731 [formation of translation preinitiation complex]
GO:0003743 [translation initiation factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005852 [eukaryotic translation initiation factor 3 complex]
GO:0006446 [regulation of translational initiation]
GO:0016282 [eukaryotic 43S preinitiation complex]
GO:0016605 [PML body]
GO:0033290 [eukaryotic 48S preinitiation complex]
Show all
 352 aa
41.4 kDa 		No 0
EIF3E-007
ENSP00000430678
ENST00000518345
E5RIT4 [Direct mapping]
Eukaryotic translation initiation factor 3 subunit E
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003743 [translation initiation factor activity]
GO:0005852 [eukaryotic translation initiation factor 3 complex]
GO:0006413 [translational initiation]
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 75 aa
8.9 kDa 		No 0
EIF3E-008
ENSP00000430839
ENST00000519627
E5RHS5 [Direct mapping]
Eukaryotic translation initiation factor 3 subunit E
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003743 [translation initiation factor activity]
GO:0005852 [eukaryotic translation initiation factor 3 complex]
GO:0006413 [translational initiation]
Show all
 226 aa
26.6 kDa 		No 0
EIF3E-010
ENSP00000429968
ENST00000521297
H0YBP5 [Direct mapping]
Eukaryotic translation initiation factor 3 subunit E
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003743 [translation initiation factor activity]
GO:0005852 [eukaryotic translation initiation factor 3 complex]
GO:0006413 [translational initiation]
Show all
 74 aa
8.4 kDa 		No 0
EIF3E-011
ENSP00000430152
ENST00000521440
H0YBR5 [Direct mapping]
Eukaryotic translation initiation factor 3 subunit E
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003743 [translation initiation factor activity]
GO:0005852 [eukaryotic translation initiation factor 3 complex]
GO:0006413 [translational initiation]
Show all
 171 aa
20.1 kDa 		No 0
EIF3E-015
ENSP00000428170
ENST00000522352
H0YAW4 [Direct mapping]
Eukaryotic translation initiation factor 3 subunit E
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003743 [translation initiation factor activity]
GO:0005515 [protein binding]
GO:0005852 [eukaryotic translation initiation factor 3 complex]
GO:0006413 [translational initiation]
Show all
 156 aa
18 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.