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GSR

GENERAL INFORMATION

Gene name

 GSR

Gene description

 Glutathione reductase

Protein class

 Cancer-related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Sub cellular location is contradicted by external data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA001538 , CAB008632
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), colorectal cancer (favourable), renal cancer (favourable) and cervical cancer (favourable).
Liver cancer p<0.001
Colorectal cancer p<0.001
Renal cancer p<0.001
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001538
CAB008632

GENE INFORMATION

Gene name

 GSR

Synonyms

Description

 Glutathione reductase (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2010]

Chromosome

 8

Cytoband

 p12

Chromosome location (bp)

 30678061 - 30727926

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104687 (version 83.38)

Entrez gene

 2936

UniProt

 P00390 (UniProt - Evidence at protein level)

neXtProt

 NX_P00390

Antibodypedia

 GSR antibodies

PROTEIN BROWSER
GSR-001
GSR-002
GSR-005
GSR-006
GSR-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GSR-001
ENSP00000221130
ENST00000221130
P00390 [Direct mapping]
Glutathione reductase, mitochondrial
V9HW90 [Target identity:100%; Query identity:100%]
Epididymis luminal protein 75
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Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302 [response to reactive oxygen species]
GO:0004362 [glutathione-disulfide reductase activity]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006749 [glutathione metabolic process]
GO:0009055 [electron carrier activity]
GO:0009897 [external side of plasma membrane]
GO:0010467 [gene expression]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0016491 [oxidoreductase activity]
GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor]
GO:0044281 [small molecule metabolic process]
GO:0045454 [cell redox homeostasis]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0050661 [NADP binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
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 522 aa
56.3 kDa 		No 0
GSR-002
ENSP00000430825
ENST00000521479
E5RI06 [Direct mapping]
Glutathione reductase, mitochondrial
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   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 145 aa
15.8 kDa 		No 0
GSR-005
ENSP00000438845
ENST00000537535
P00390 [Direct mapping]
Glutathione reductase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302 [response to reactive oxygen species]
GO:0004362 [glutathione-disulfide reductase activity]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006749 [glutathione metabolic process]
GO:0009055 [electron carrier activity]
GO:0010467 [gene expression]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0016491 [oxidoreductase activity]
GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor]
GO:0044281 [small molecule metabolic process]
GO:0045454 [cell redox homeostasis]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0050661 [NADP binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 440 aa
47.3 kDa 		No 0
GSR-006
ENSP00000444559
ENST00000541648
P00390 [Direct mapping]
Glutathione reductase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302 [response to reactive oxygen species]
GO:0004362 [glutathione-disulfide reductase activity]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006749 [glutathione metabolic process]
GO:0009055 [electron carrier activity]
GO:0010467 [gene expression]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0016491 [oxidoreductase activity]
GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor]
GO:0044281 [small molecule metabolic process]
GO:0045454 [cell redox homeostasis]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0050661 [NADP binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 469 aa
50.5 kDa 		No 0
GSR-007
ENSP00000445516
ENST00000546342
P00390 [Direct mapping]
Glutathione reductase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302 [response to reactive oxygen species]
GO:0004362 [glutathione-disulfide reductase activity]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006749 [glutathione metabolic process]
GO:0009055 [electron carrier activity]
GO:0010467 [gene expression]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0016491 [oxidoreductase activity]
GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor]
GO:0044281 [small molecule metabolic process]
GO:0045454 [cell redox homeostasis]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0050661 [NADP binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 493 aa
53 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.