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This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2010]
Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000302 [response to reactive oxygen species] GO:0004362 [glutathione-disulfide reductase activity] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005829 [cytosol] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006749 [glutathione metabolic process] GO:0009055 [electron carrier activity] GO:0009897 [external side of plasma membrane] GO:0010467 [gene expression] GO:0015949 [nucleobase-containing small molecule interconversion] GO:0016491 [oxidoreductase activity] GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor] GO:0044281 [small molecule metabolic process] GO:0045454 [cell redox homeostasis] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome]
Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000302 [response to reactive oxygen species] GO:0004362 [glutathione-disulfide reductase activity] GO:0005759 [mitochondrial matrix] GO:0005829 [cytosol] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006749 [glutathione metabolic process] GO:0009055 [electron carrier activity] GO:0010467 [gene expression] GO:0015949 [nucleobase-containing small molecule interconversion] GO:0016491 [oxidoreductase activity] GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor] GO:0044281 [small molecule metabolic process] GO:0045454 [cell redox homeostasis] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome]
Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000302 [response to reactive oxygen species] GO:0004362 [glutathione-disulfide reductase activity] GO:0005759 [mitochondrial matrix] GO:0005829 [cytosol] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006749 [glutathione metabolic process] GO:0009055 [electron carrier activity] GO:0010467 [gene expression] GO:0015949 [nucleobase-containing small molecule interconversion] GO:0016491 [oxidoreductase activity] GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor] GO:0044281 [small molecule metabolic process] GO:0045454 [cell redox homeostasis] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome]
Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302 [response to reactive oxygen species] GO:0004362 [glutathione-disulfide reductase activity] GO:0005759 [mitochondrial matrix] GO:0005829 [cytosol] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006749 [glutathione metabolic process] GO:0009055 [electron carrier activity] GO:0010467 [gene expression] GO:0015949 [nucleobase-containing small molecule interconversion] GO:0016491 [oxidoreductase activity] GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor] GO:0044281 [small molecule metabolic process] GO:0045454 [cell redox homeostasis] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome]
