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ARHGEF10

GENERAL INFORMATION

Gene name

 ARHGEF10

Gene description

 Rho guanine nucleotide exchange factor (GEF) 10

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic or nuclear expression in selected tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA024649
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 ARHGEF10 (HGNC Symbol)

Synonyms

 Gef10, KIAA0294

Description

 Rho guanine nucleotide exchange factor (GEF) 10 (HGNC Symbol)

Entrez gene summary

 This gene encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Chromosome

 8

Cytoband

 p23.3

Chromosome location (bp)

 1823976 - 1958641

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104728 (version 83.38)

Entrez gene

 9639

UniProt

 O15013 (UniProt - Evidence at protein level)

neXtProt

 NX_O15013

Antibodypedia

 ARHGEF10 antibodies

PROTEIN BROWSER
ARHGEF10-001
ARHGEF10-002
ARHGEF10-003
ARHGEF10-004
ARHGEF10-201
ARHGEF10-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARHGEF10-001
ENSP00000431012
ENST00000518288
O15013 [Direct mapping]
Rho guanine nucleotide exchange factor 10
Show all
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0019894 [kinesin binding]
GO:0022011 [myelination in peripheral nervous system]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0051298 [centrosome duplication]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0090307 [mitotic spindle assembly]
GO:0090630 [activation of GTPase activity]
Show all
 1368 aa
151.5 kDa 		No 0
ARHGEF10-002
ENSP00000427909
ENST00000520359
O15013 [Direct mapping]
Rho guanine nucleotide exchange factor 10
Show all
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0019894 [kinesin binding]
GO:0022011 [myelination in peripheral nervous system]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0051298 [centrosome duplication]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0090307 [mitotic spindle assembly]
GO:0090630 [activation of GTPase activity]
Show all
 1306 aa
144.3 kDa 		No 0
ARHGEF10-003
ENSP00000340297
ENST00000349830
O15013 [Direct mapping]
Rho guanine nucleotide exchange factor 10
Show all
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0019894 [kinesin binding]
GO:0022011 [myelination in peripheral nervous system]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0051298 [centrosome duplication]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0090307 [mitotic spindle assembly]
GO:0090630 [activation of GTPase activity]
Show all
 1344 aa
148.9 kDa 		No 0
ARHGEF10-004
ENSP00000427768
ENST00000522435
H0YAN8 [Direct mapping]
Rho guanine nucleotide exchange factor 10
Show all
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0022011 [myelination in peripheral nervous system]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0090307 [mitotic spindle assembly]
Show all
 988 aa
109.7 kDa 		No 0
ARHGEF10-201
ENSP00000381568
ENST00000398560
E9PB39 [Direct mapping]
Rho guanine nucleotide exchange factor 10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0022011 [myelination in peripheral nervous system]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0090307 [mitotic spindle assembly]
Show all
 380 aa
43.7 kDa 		No 0
ARHGEF10-202
ENSP00000381571
ENST00000398564
O15013 [Direct mapping]
Rho guanine nucleotide exchange factor 10
Show all
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0019894 [kinesin binding]
GO:0022011 [myelination in peripheral nervous system]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0051298 [centrosome duplication]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0090307 [mitotic spindle assembly]
GO:0090630 [activation of GTPase activity]
Show all
 1369 aa
151.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.