Fields »
ABOUT
HELP
BLOG
MCM4

GENERAL INFORMATION

Gene name

 MCM4

Gene description

 Minichromosome maintenance complex component 4

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression at variable levels in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA004873 , CAB004497
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable), melanoma (unfavourable), liver cancer (unfavourable), colorectal cancer (favourable), pancreatic cancer (unfavourable) and renal cancer (unfavourable).
Endometrial cancer p<0.001
Melanoma p<0.001
Liver cancer p<0.001
Colorectal cancer p<0.001
Pancreatic cancer p<0.001
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA004873
CAB004497

GENE INFORMATION

Gene name

 MCM4 (HGNC Symbol)

Synonyms

 CDC21, CDC54, hCdc21, MGC33310, P1-Cdc21

Description

 Minichromosome maintenance complex component 4 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 q11.21

Chromosome location (bp)

 47960185 - 47978160

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104738 (version 83.38)

Entrez gene

 4173

UniProt

 P33991 (UniProt - Evidence at protein level)

neXtProt

 NX_P33991

Antibodypedia

 MCM4 antibodies

PROTEIN BROWSER
MCM4-001
MCM4-004
MCM4-008
MCM4-009
MCM4-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MCM4-001
ENSP00000262105
ENST00000262105
P33991 [Direct mapping]
DNA replication licensing factor MCM4
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0003677 [DNA binding]
GO:0003678 [DNA helicase activity]
GO:0003697 [single-stranded DNA binding]
GO:0004003 [ATP-dependent DNA helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006268 [DNA unwinding involved in DNA replication]
GO:0006270 [DNA replication initiation]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0016020 [membrane]
GO:0042555 [MCM complex]
Show all
 863 aa
96.6 kDa 		No 0
MCM4-004
ENSP00000430194
ENST00000523944
P33991 [Direct mapping]
DNA replication licensing factor MCM4
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0003677 [DNA binding]
GO:0004003 [ATP-dependent DNA helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006270 [DNA replication initiation]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0016020 [membrane]
GO:0042555 [MCM complex]
Show all
 863 aa
96.6 kDa 		No 0
MCM4-008
ENSP00000430329
ENST00000518221
E5RFR3 [Direct mapping]
DNA replication licensing factor MCM4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 141 aa
14.8 kDa 		No 0
MCM4-009
ENSP00000428833
ENST00000519170
E5RFJ8 [Direct mapping]
DNA replication licensing factor MCM4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
Show all
 212 aa
23.5 kDa 		No 0
MCM4-011
ENSP00000427875
ENST00000520637
E5RG31 [Direct mapping]
DNA replication licensing factor MCM4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005524 [ATP binding]
GO:0006260 [DNA replication]
Show all
 279 aa
31.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.