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HNRNPL

GENERAL INFORMATION

Gene name

 HNRNPL

Gene description

 Heterogeneous nuclear ribonucleoprotein L

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA051748 , HPA052661 , CAB016326
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA051748
HPA052661
CAB016326

GENE INFORMATION

Gene name

 HNRNPL (HGNC Symbol)

Synonyms

 HNRPL

Description

 Heterogeneous nuclear ribonucleoprotein L (HGNC Symbol)

Entrez gene summary

 Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.2

Chromosome location (bp)

 38836388 - 38852347

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104824 (version 83.38)

Entrez gene

 3191

UniProt

 P14866 (UniProt - Evidence at protein level)

neXtProt

 NX_P14866

Antibodypedia

 HNRNPL antibodies

PROTEIN BROWSER
HNRNPL-001
HNRNPL-002
HNRNPL-005
HNRNPL-014
HNRNPL-015

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HNRNPL-001
ENSP00000221419
ENST00000221419
P14866 [Direct mapping]
Heterogeneous nuclear ribonucleoprotein L
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006396 [RNA processing]
GO:0006397 [mRNA processing]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0030529 [ribonucleoprotein complex]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044822 [poly(A) RNA binding]
GO:0070062 [extracellular exosome]
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 589 aa
64.1 kDa 		No 0
HNRNPL-002
ENSP00000470231
ENST00000600873
P14866 [Direct mapping]
Heterogeneous nuclear ribonucleoprotein L
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006396 [RNA processing]
GO:0006397 [mRNA processing]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0030529 [ribonucleoprotein complex]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044822 [poly(A) RNA binding]
GO:0070062 [extracellular exosome]
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 456 aa
50.6 kDa 		No 0
HNRNPL-005
ENSP00000469349
ENST00000601449
M0QXS5 [Direct mapping]
Heterogeneous nuclear ribonucleoprotein L
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005634 [nucleus]
GO:0006397 [mRNA processing]
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 530 aa
58.4 kDa 		No 0
HNRNPL-014
ENSP00000469913
ENST00000601813
M0QYL7 [Direct mapping]
Heterogeneous nuclear ribonucleoprotein L
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
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 198 aa
21.9 kDa 		No 0
HNRNPL-015
ENSP00000472150
ENST00000600233
M0R1W6 [Direct mapping]
Heterogeneous nuclear ribonucleoprotein L
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005634 [nucleus]
GO:0006397 [mRNA processing]
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 220 aa
24.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.