Cell atlas - LHB - The Human Protein Atlas

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LHB

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	LHB
Gene description	Luteinizing hormone beta polypeptide
Protein class	Cancer-related genes Disease related genes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. HPA038925 , HPA038934
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA038925	A-431	Cytosol
HPA038925	U-2 OS	Cytosol
HPA038934	A-431	Cytosol
HPA038934	U-2 OS	Cytosol
HPA038934	U-251 MG	Cytosol

GENE INFORMATION
Gene name	LHB (HGNC Symbol)
Synonyms	CGB4, hLHB, LSH-B
Description	Luteinizing hormone beta polypeptide (HGNC Symbol)
Entrez gene summary	This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.33
Chromosome location (bp)	49015980 - 49017090
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104826 (version 83.38)
Entrez gene	3972
UniProt	P01229 (UniProt - Evidence at protein level)
neXtProt	NX_P01229
Antibodypedia	LHB antibodies

PROTEIN BROWSER

LHB-001	LHB-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LHB-001 ENSP00000221421 ENST00000221421	P01229 [Direct mapping] Lutropin subunit beta A0A0F7RQE6 [Target identity:100%; Query identity:100%] Luteinizing hormone beta polypeptide; Luteinizing hormone beta subunit Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Show all	GO:0005102 [receptor binding] GO:0005179 [hormone activity] GO:0005576 [extracellular region] GO:0006701 [progesterone biosynthetic process] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0008584 [male gonad development] GO:0016486 [peptide hormone processing] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] Show all	141 aa 15.3 kDa	Yes	0
LHB-201 ENSP00000375742 ENST00000391869	J3QT02 [Direct mapping] Lutropin subunit beta Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] Show all	154 aa 16.7 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.