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LHB

GENERAL INFORMATION

Gene name

 LHB

Gene description

 Luteinizing hormone beta polypeptide

Protein class

 Cancer-related genes
Disease related genes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Mixed
HPA (normal tissue):Tissue enhanced (duodenum, pancreas, testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Highly expressed in the pituitary gland.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Caution, targets protein from more than one gene. Antibody staining consistent with external characterization data and GTEx RNA expression data.

Reliability score

 Supported based on 4 antibodies.
HPA038925 , HPA038934 , CAB022241 , CAB022707
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA038925
HPA038934
CAB022241
CAB022707

GENE INFORMATION

Gene name

 LHB (HGNC Symbol)

Synonyms

 CGB4, hLHB, LSH-B

Description

 Luteinizing hormone beta polypeptide (HGNC Symbol)

Entrez gene summary

 This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.33

Chromosome location (bp)

 49015980 - 49017090

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104826 (version 83.38)

Entrez gene

 3972

UniProt

 P01229 (UniProt - Evidence at protein level)

neXtProt

 NX_P01229

Antibodypedia

 LHB antibodies

PROTEIN BROWSER
LHB-001
LHB-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LHB-001
ENSP00000221421
ENST00000221421
P01229 [Direct mapping]
Lutropin subunit beta
A0A0F7RQE6 [Target identity:100%; Query identity:100%]
Luteinizing hormone beta polypeptide; Luteinizing hormone beta subunit
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
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GO:0005102 [receptor binding]
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
GO:0006701 [progesterone biosynthetic process]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0008584 [male gonad development]
GO:0016486 [peptide hormone processing]
GO:0044267 [cellular protein metabolic process]
GO:0070062 [extracellular exosome]
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 141 aa
15.3 kDa 		Yes 0
LHB-201
ENSP00000375742
ENST00000391869
J3QT02 [Direct mapping]
Lutropin subunit beta
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
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GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
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 154 aa
16.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.