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DOT1L

GENERAL INFORMATION

Gene name

 DOT1L

Gene description

 DOT1-like histone H3K79 methyltransferase

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enriched (testis)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable) and head and neck cancer (favourable).
Endometrial cancer p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 DOT1L (HGNC Symbol)

Synonyms

 DOT1, KIAA1814, KMT4

Description

 DOT1-like histone H3K79 methyltransferase (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011]

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 2164149 - 2232578

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104885 (version 83.38)

Entrez gene

 84444

UniProt

 Q8TEK3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TEK3

Antibodypedia

 DOT1L antibodies

PROTEIN BROWSER
DOT1L-001
DOT1L-003
DOT1L-007
DOT1L-008
DOT1L-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DOT1L-001
ENSP00000381657
ENST00000398665
Q8TEK3 [Direct mapping]
Histone-lysine N-methyltransferase, H3 lysine-79 specific
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006342 [chromatin silencing]
GO:0008134 [transcription factor binding]
GO:0018024 [histone-lysine N-methyltransferase activity]
GO:0031151 [histone methyltransferase activity (H3-K79 specific)]
GO:0034729 [histone H3-K79 methylation]
GO:0042054 [histone methyltransferase activity]
GO:0046425 [regulation of JAK-STAT cascade]
GO:0051726 [regulation of cell cycle]
GO:2000677 [regulation of transcription regulatory region DNA binding]
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 1537 aa
164.9 kDa 		No 0
DOT1L-003
ENSP00000404284
ENST00000452696
C9JH95 [Direct mapping]
Histone-lysine N-methyltransferase, H3 lysine-79 specific
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0018024 [histone-lysine N-methyltransferase activity]
GO:0031151 [histone methyltransferase activity (H3-K79 specific)]
GO:0034729 [histone H3-K79 methylation]
GO:0051726 [regulation of cell cycle]
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 208 aa
24.3 kDa 		No 0
DOT1L-007
ENSP00000412916
ENST00000446286
H7C3N3 [Direct mapping]
Histone-lysine N-methyltransferase, H3 lysine-79-specific
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 125 aa
11.9 kDa 		No 0
DOT1L-008
ENSP00000407411
ENST00000457590
H7C2S2 [Direct mapping]
Histone-lysine N-methyltransferase, H3 lysine-79-specific
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0031151 [histone methyltransferase activity (H3-K79 specific)]
GO:0034729 [histone H3-K79 methylation]
GO:0051726 [regulation of cell cycle]
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 653 aa
65.5 kDa 		No 0
DOT1L-009
ENSP00000476469
ENST00000586024
V9GY76 [Direct mapping]
Histone-lysine N-methyltransferase, H3 lysine-79-specific
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0031151 [histone methyltransferase activity (H3-K79 specific)]
GO:0034729 [histone H3-K79 methylation]
GO:0051726 [regulation of cell cycle]
Show all
 142 aa
16.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.