Tissue expression of DOT1L - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	DOT1L
Gene description	DOT1-like histone H3K79 methyltransferase
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (testis)
GTEx:	Tissue enriched (testis)
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	DOT1L (HGNC Symbol)
Synonyms	DOT1, KIAA1814, KMT4
Description	DOT1-like histone H3K79 methyltransferase (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	2164149 - 2232578
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104885 (version 83.38)
Entrez gene	84444
UniProt	Q8TEK3 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TEK3
Antibodypedia	DOT1L antibodies

PROTEIN BROWSER

DOT1L-001	DOT1L-003	DOT1L-007	DOT1L-008	DOT1L-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DOT1L-001 ENSP00000381657 ENST00000398665	Q8TEK3 [Direct mapping] Histone-lysine N-methyltransferase, H3 lysine-79 specific Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006325 [chromatin organization] GO:0006342 [chromatin silencing] GO:0008134 [transcription factor binding] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0031151 [histone methyltransferase activity (H3-K79 specific)] GO:0034729 [histone H3-K79 methylation] GO:0042054 [histone methyltransferase activity] GO:0046425 [regulation of JAK-STAT cascade] GO:0051726 [regulation of cell cycle] GO:2000677 [regulation of transcription regulatory region DNA binding] Show all	1537 aa 164.9 kDa	No	0
DOT1L-003 ENSP00000404284 ENST00000452696	C9JH95 [Direct mapping] Histone-lysine N-methyltransferase, H3 lysine-79 specific Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0031151 [histone methyltransferase activity (H3-K79 specific)] GO:0034729 [histone H3-K79 methylation] GO:0051726 [regulation of cell cycle] Show all	208 aa 24.3 kDa	No	0
DOT1L-007 ENSP00000412916 ENST00000446286	H7C3N3 [Direct mapping] Histone-lysine N-methyltransferase, H3 lysine-79-specific Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		125 aa 11.9 kDa	No	0
DOT1L-008 ENSP00000407411 ENST00000457590	H7C2S2 [Direct mapping] Histone-lysine N-methyltransferase, H3 lysine-79-specific Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0031151 [histone methyltransferase activity (H3-K79 specific)] GO:0034729 [histone H3-K79 methylation] GO:0051726 [regulation of cell cycle] Show all	653 aa 65.5 kDa	No	0
DOT1L-009 ENSP00000476469 ENST00000586024	V9GY76 [Direct mapping] Histone-lysine N-methyltransferase, H3 lysine-79-specific Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0031151 [histone methyltransferase activity (H3-K79 specific)] GO:0034729 [histone H3-K79 methylation] GO:0051726 [regulation of cell cycle] Show all	142 aa 16.2 kDa	No	0