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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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SLC17A7
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    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

SLC17A7

Gene description

Solute carrier family 17 (vesicular glutamate transporter), member 7

Protein class

Predicted membrane proteins
Transporters

Predicted localization

Membrane

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enriched (glioma)
HPA (cell line):Cell line enhanced (HMC-1, K-562, SCLC-21H)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective expression in CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA050458 , HPA063679 , CAB037183
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA050458
HPA063679
CAB037183

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Few cases of melanomas showed strong cytoplasmic and occasional membranous immunoreactivity. Remaining tumour tissues were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Several breast, colorectal, prostate cancers along with few glioma, endometrial, ovarian, urothelial cancers showed weak to moderate cytoplasmic positivity. Pancreas, colorectal and stomach cancer exhibited additional membranous positivity. Other cancer tissues were generally negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Many cases of colorectal cancers and fractions of cases in pancreatic, gastric, ovarian and lung cancers showed moderate to strong cytoplasmic positivity. Most remaining tumour cells were negative.

GENE INFORMATION

Gene name

SLC17A7 (HGNC Symbol)

Synonyms

BNPI, VGLUT1

Description

Solute carrier family 17 (vesicular glutamate transporter), member 7 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

q13.33

Chromosome location (bp)

49429401 - 49442360

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000104888 (version 83.38)

Entrez gene

57030

UniProt

Q9P2U7 (UniProt - Evidence at transcript level)

neXtProt

NX_Q9P2U7

Antibodypedia

SLC17A7 antibodies

PROTEIN BROWSER

SLC17A7-001
SLC17A7-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SLC17A7-001
ENSP00000221485
ENST00000221485
Q9P2U7 [Direct mapping]
Vesicular glutamate transporter 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003407 [neural retina development]
GO:0005313 [L-glutamate transmembrane transporter activity]
GO:0005315 [inorganic phosphate transmembrane transporter activity]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0006817 [phosphate ion transport]
GO:0006821 [chloride transport]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0007420 [brain development]
GO:0007616 [long-term memory]
GO:0008021 [synaptic vesicle]
GO:0008068 [extracellular-glutamate-gated chloride channel activity]
GO:0014047 [glutamate secretion]
GO:0015319 [sodium:inorganic phosphate symporter activity]
GO:0015321 [sodium-dependent phosphate transmembrane transporter activity]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0030672 [synaptic vesicle membrane]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0035435 [phosphate ion transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0042137 [sequestering of neurotransmitter]
GO:0043229 [intracellular organelle]
GO:0044300 [cerebellar mossy fiber]
GO:0044341 [sodium-dependent phosphate transport]
GO:0045202 [synapse]
GO:0048786 [presynaptic active zone]
GO:0051938 [L-glutamate import]
GO:0055085 [transmembrane transport]
GO:0060076 [excitatory synapse]
GO:0060079 [excitatory postsynaptic potential]
GO:0060203 [clathrin-sculpted glutamate transport vesicle membrane]
GO:0089711 [L-glutamate transmembrane transport]
GO:0097401 [synaptic vesicle lumen acidification]
GO:1902476 [chloride transmembrane transport]
Show all
560 aa
61.6 kDa
No >9
SLC17A7-002
ENSP00000470338
ENST00000600601
Q9P2U7 [Direct mapping]
Vesicular glutamate transporter 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005313 [L-glutamate transmembrane transporter activity]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0006817 [phosphate ion transport]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0014047 [glutamate secretion]
GO:0015319 [sodium:inorganic phosphate symporter activity]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0030672 [synaptic vesicle membrane]
GO:0035435 [phosphate ion transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0044341 [sodium-dependent phosphate transport]
GO:0055085 [transmembrane transport]
GO:0060203 [clathrin-sculpted glutamate transport vesicle membrane]
GO:0089711 [L-glutamate transmembrane transport]
Show all
493 aa
53.9 kDa
No >9

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