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SLC17A7

GENERAL INFORMATION

Gene name

 SLC17A7

Gene description

 Solute carrier family 17 (vesicular glutamate transporter), member 7

Protein class

 Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Group enriched (cerebellum, cerebral cortex, hippocampus)
FANTOM5:Group enriched (brain, cerebellum, hippocampus, retina)

Protein evidence

 Evidence at protein level

Protein expression

 Selective expression in CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA050458 , HPA063679 , CAB037183
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Hippocampus

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebellum, cerebral cortex, hippocampus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (brain, cerebellum, hippocampus, retina)

GENE INFORMATION

Gene name

 SLC17A7 (HGNC Symbol)

Synonyms

 BNPI, VGLUT1

Description

 Solute carrier family 17 (vesicular glutamate transporter), member 7 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.33

Chromosome location (bp)

 49429401 - 49442360

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104888 (version 83.38)

Entrez gene

 57030

UniProt

 Q9P2U7 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9P2U7

Antibodypedia

 SLC17A7 antibodies

PROTEIN BROWSER
SLC17A7-001
SLC17A7-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC17A7-001
ENSP00000221485
ENST00000221485
Q9P2U7 [Direct mapping]
Vesicular glutamate transporter 1
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003407 [neural retina development]
GO:0005313 [L-glutamate transmembrane transporter activity]
GO:0005315 [inorganic phosphate transmembrane transporter activity]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0006817 [phosphate ion transport]
GO:0006821 [chloride transport]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0007420 [brain development]
GO:0007616 [long-term memory]
GO:0008021 [synaptic vesicle]
GO:0008068 [extracellular-glutamate-gated chloride channel activity]
GO:0014047 [glutamate secretion]
GO:0015319 [sodium:inorganic phosphate symporter activity]
GO:0015321 [sodium-dependent phosphate transmembrane transporter activity]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0030672 [synaptic vesicle membrane]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0035435 [phosphate ion transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0042137 [sequestering of neurotransmitter]
GO:0043229 [intracellular organelle]
GO:0044300 [cerebellar mossy fiber]
GO:0044341 [sodium-dependent phosphate transport]
GO:0045202 [synapse]
GO:0048786 [presynaptic active zone]
GO:0051938 [L-glutamate import]
GO:0055085 [transmembrane transport]
GO:0060076 [excitatory synapse]
GO:0060079 [excitatory postsynaptic potential]
GO:0060203 [clathrin-sculpted glutamate transport vesicle membrane]
GO:0089711 [L-glutamate transmembrane transport]
GO:0097401 [synaptic vesicle lumen acidification]
GO:1902476 [chloride transmembrane transport]
Show all
 560 aa
61.6 kDa 		No >9
SLC17A7-002
ENSP00000470338
ENST00000600601
Q9P2U7 [Direct mapping]
Vesicular glutamate transporter 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005313 [L-glutamate transmembrane transporter activity]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0006817 [phosphate ion transport]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0014047 [glutamate secretion]
GO:0015319 [sodium:inorganic phosphate symporter activity]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0030672 [synaptic vesicle membrane]
GO:0035435 [phosphate ion transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0044341 [sodium-dependent phosphate transport]
GO:0055085 [transmembrane transport]
GO:0060203 [clathrin-sculpted glutamate transport vesicle membrane]
GO:0089711 [L-glutamate transmembrane transport]
Show all
 493 aa
53.9 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.