Tissue expression of CD37 - Summary - The Human Protein Atlas

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CD37

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CD37
Gene description	CD37 molecule
Protein class	CD markers Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (lymph node, spleen)
GTEx:	Expressed in all
FANTOM5:	Group enriched (appendix, lung, lymph node, spleen, tonsil)

Protein evidence

Evidence at protein level

Protein expression

Selective cytoplasmic and membranous expression in a subset of immune cells, mainly in germinal reaction centers of lymphoid tissue.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA032120 , HPA032121 , CAB002492
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lymph node, spleen)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (appendix, lung, lymph node, spleen, tonsil)

GENE INFORMATION
Gene name	CD37 (HGNC Symbol)
Synonyms	TSPAN26
Description	CD37 molecule (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.33
Chromosome location (bp)	49335171 - 49343335
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104894 (version 83.38)
Entrez gene	951
UniProt	P11049 (UniProt - Evidence at protein level)
neXtProt	NX_P11049
Antibodypedia	CD37 antibodies

PROTEIN BROWSER

CD37-001	CD37-004	CD37-006	CD37-007	CD37-012	CD37-013	CD37-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD37-001 ENSP00000325708 ENST00000323906	P11049 [Direct mapping] Leukocyte antigen CD37 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001772 [immunological synapse] GO:0002639 [positive regulation of immunoglobulin production] GO:0002920 [regulation of humoral immune response] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0008285 [negative regulation of cell proliferation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030886 [negative regulation of myeloid dendritic cell activation] GO:0042832 [defense response to protozoan] GO:0050688 [regulation of defense response to virus] GO:0070062 [extracellular exosome] Show all	281 aa 31.7 kDa	No	4
CD37-004 ENSP00000441037 ENST00000535669	B7ZAN3 [Direct mapping] Tetraspanin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	270 aa 30.3 kDa	No	4
CD37-006 ENSP00000413151 ENST00000426897	P11049 [Direct mapping] Leukocyte antigen CD37 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001772 [immunological synapse] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	213 aa 24 kDa	No	2
CD37-007 ENSP00000470394 ENST00000598095	P11049 [Direct mapping] Leukocyte antigen CD37 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001772 [immunological synapse] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	202 aa 22.6 kDa	No	2
CD37-012 ENSP00000470260 ENST00000595660	M0QZ33 [Direct mapping] Leukocyte antigen CD37 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	161 aa 17.6 kDa	No	3
CD37-013 ENSP00000471078 ENST00000597602	M0R083 [Direct mapping] Leukocyte antigen CD37 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		27 aa 2.9 kDa	No	0
CD37-015 ENSP00000470683 ENST00000594743	M0QZP6 [Direct mapping] Leukocyte antigen CD37 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	254 aa 27.6 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.