Expression of CLC in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CLC
Gene description	Charcot-Leyden crystal galectin
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (colorectal cancer)
HPA (cell line):	Cell line enriched (HMC-1)
HPA (normal tissue):	Tissue enhanced (bone marrow)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in a fraction of hematopoietic cells and in subsets of leukocytes in several tissues, including intestinal tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 1 antibody. HPA041751
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (colorectal cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA041751

GENE INFORMATION
Gene name	CLC (HGNC Symbol)
Synonyms	Gal-10, LGALS10, MGC149659
Description	Charcot-Leyden crystal galectin (HGNC Symbol)
Entrez gene summary	Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	39731250 - 39738028
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105205 (version 83.38)
Entrez gene	1178
UniProt	Q05315 (UniProt - Evidence at protein level)
neXtProt	NX_Q05315
Antibodypedia	CLC antibodies

PROTEIN BROWSER

CLC-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLC-001 ENSP00000221804 ENST00000221804	Q05315 [Direct mapping] Galectin-10 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002667 [regulation of T cell anergy] GO:0002724 [regulation of T cell cytokine production] GO:0004622 [lysophospholipase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0007275 [multicellular organismal development] GO:0030246 [carbohydrate binding] GO:0046006 [regulation of activated T cell proliferation] GO:0070231 [T cell apoptotic process] GO:0097153 [cysteine-type endopeptidase activity involved in apoptotic process] Show all	142 aa 16.5 kDa	No	0