Expression of AKT2 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	AKT2
Gene description	V-akt murine thymoma viral oncogene homolog 2
Protein class	Cancer-related genes Disease related genes Enzymes Potential drug targets Predicted intracellular proteins RAS pathway related proteins
Predicted localization	Intracellular
Number of transcripts	22
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. CAB004204
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable) and prostate cancer (unfavourable).
Endometrial cancer p<0.001 Prostate cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

CAB004204

GENE INFORMATION
Gene name	AKT2
Synonyms
Description	V-akt murine thymoma viral oncogene homolog 2 (HGNC Symbol)
Entrez gene summary	This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	40230317 - 40285536
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105221 (version 83.38)
Entrez gene	208
UniProt	P31751 (UniProt - Evidence at protein level)
neXtProt	NX_P31751
Antibodypedia	AKT2 antibodies

PROTEIN BROWSER

AKT2-001	AKT2-005	AKT2-006	AKT2-007	AKT2-008	AKT2-010	AKT2-011	AKT2-012	AKT2-014	AKT2-021	AKT2-025	AKT2-027	AKT2-029	AKT2-030	AKT2-032	AKT2-033	AKT2-035	AKT2-036	AKT2-041	AKT2-042	AKT2-045	AKT2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AKT2-001 ENSP00000375892 ENST00000392038	P31751 [Direct mapping] RAC-beta serine/threonine-protein kinase Show all	Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001934 [positive regulation of protein phosphorylation] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005080 [protein kinase C binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0005978 [glycogen biosynthetic process] GO:0006006 [glucose metabolic process] GO:0006417 [regulation of translation] GO:0006464 [cellular protein modification process] GO:0006468 [protein phosphorylation] GO:0006970 [response to osmotic stress] GO:0007165 [signal transduction] GO:0008286 [insulin receptor signaling pathway] GO:0008643 [carbohydrate transport] GO:0009967 [positive regulation of signal transduction] GO:0010628 [positive regulation of gene expression] GO:0010748 [negative regulation of plasma membrane long-chain fatty acid transport] GO:0010907 [positive regulation of glucose metabolic process] GO:0014850 [response to muscle activity] GO:0030334 [regulation of cell migration] GO:0030335 [positive regulation of cell migration] GO:0031340 [positive regulation of vesicle fusion] GO:0031667 [response to nutrient levels] GO:0031982 [vesicle] GO:0032000 [positive regulation of fatty acid beta-oxidation] GO:0032287 [peripheral nervous system myelin maintenance] GO:0032587 [ruffle membrane] GO:0032593 [insulin-responsive compartment] GO:0032868 [response to insulin] GO:0032869 [cellular response to insulin stimulus] GO:0032870 [cellular response to hormone stimulus] GO:0033119 [negative regulation of RNA splicing] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0043491 [protein kinase B signaling] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045444 [fat cell differentiation] GO:0045725 [positive regulation of glycogen biosynthetic process] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046326 [positive regulation of glucose import] GO:0050927 [positive regulation of positive chemotaxis] GO:0060644 [mammary gland epithelial cell differentiation] GO:0061024 [membrane organization] GO:0065002 [intracellular protein transmembrane transport] GO:0071156 [regulation of cell cycle arrest] GO:0071407 [cellular response to organic cyclic compound] GO:0072659 [protein localization to plasma membrane] GO:0090314 [positive regulation of protein targeting to membrane] GO:0090630 [activation of GTPase activity] GO:2000147 [positive regulation of cell motility] GO:2001275 [positive regulation of glucose import in response to insulin stimulus] Show all	481 aa 55.8 kDa	No	0
AKT2-005 ENSP00000404083 ENST00000452077	E7EVP8 [Direct mapping] RAC-beta serine/threonine-protein kinase Show all	Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014) Show all		134 aa 15.7 kDa	No	0
AKT2-006 ENSP00000396532 ENST00000456441	C9JC83 [Direct mapping] RAC-beta serine/threonine-protein kinase Show all	Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014) Show all		107 aa 12.8 kDa	No	0
AKT2-007 ENSP00000403842 ENST00000423127	C9JIJ1 [Direct mapping] RAC-beta serine/threonine-protein kinase Show all	Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014) Show all		119 aa 14.1 kDa	No	0
AKT2-008 ENSP00000392458 ENST00000416994	C9J258 [Direct mapping] RAC-beta serine/threonine-protein kinase Show all	Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014) Show all		95 aa 11.3 kDa	No	0
AKT2-010 ENSP00000407999 ENST00000416362	A8MX96 [Direct mapping] RAC-beta serine/threonine-protein kinase Show all	Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014) Show all		133 aa 15.5 kDa	No	0
AKT2-011 ENSP00000403890 ENST00000427375	C9JIF6 [Direct mapping] RAC-beta serine/threonine-protein kinase Show all	Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014) Show all		67 aa 7.9 kDa	No	0
AKT2-012 ENSP00000396968 ENST00000441941	C9JHS6 [Direct mapping] RAC-beta serine/threonine-protein kinase Show all	Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	184 aa 21.3 kDa	No	0
AKT2-014 ENSP00000375891 ENST00000392037	A8MX96 [Direct mapping] RAC-beta serine/threonine-protein kinase Show all	Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014) Show all		133 aa 15.5 kDa	No	0
AKT2-021 ENSP00000472382 ENST00000497948	M0R283 [Direct mapping] RAC-beta serine/threonine-protein kinase Show all	Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	117 aa 13.1 kDa	No	0
AKT2-025 ENSP00000471369 ENST00000579047	M0R0P9 [Direct mapping] RAC-beta serine/threonine-protein kinase Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	450 aa 51.6 kDa	No	0
AKT2-027 ENSP00000309428 ENST00000311278	P31751 [Direct mapping] RAC-beta serine/threonine-protein kinase Show all	Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0001934 [positive regulation of protein phosphorylation] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0005978 [glycogen biosynthetic process] GO:0006006 [glucose metabolic process] GO:0006417 [regulation of translation] GO:0006464 [cellular protein modification process] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0008286 [insulin receptor signaling pathway] GO:0008643 [carbohydrate transport] GO:0010748 [negative regulation of plasma membrane long-chain fatty acid transport] GO:0010907 [positive regulation of glucose metabolic process] GO:0030334 [regulation of cell migration] GO:0031340 [positive regulation of vesicle fusion] GO:0032000 [positive regulation of fatty acid beta-oxidation] GO:0032587 [ruffle membrane] GO:0032869 [cellular response to insulin stimulus] GO:0045444 [fat cell differentiation] GO:0045725 [positive regulation of glycogen biosynthetic process] GO:0046326 [positive regulation of glucose import] GO:0060644 [mammary gland epithelial cell differentiation] GO:0061024 [membrane organization] GO:0065002 [intracellular protein transmembrane transport] GO:0071156 [regulation of cell cycle arrest] GO:0090314 [positive regulation of protein targeting to membrane] GO:2000147 [positive regulation of cell motility] Show all	438 aa 51.1 kDa	No	0
AKT2-029 ENSP00000462022 ENST00000578123	J3KRI8 [Direct mapping] RAC-beta serine/threonine-protein kinase Show all	Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014) Show all		130 aa 15.2 kDa	No	0
AKT2-030 ENSP00000462715 ENST00000583859	J3KSY8 [Direct mapping] RAC-beta serine/threonine-protein kinase Show all	Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014) Show all		99 aa 11.9 kDa	No	0
AKT2-032 ENSP00000463806 ENST00000580747	C9J258 [Direct mapping] RAC-beta serine/threonine-protein kinase Show all	Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014) Show all		95 aa 11.3 kDa	No	0
AKT2-033 ENSP00000463686 ENST00000486368	J3QLS6 [Direct mapping] RAC-beta serine/threonine-protein kinase Show all	Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014) Show all		157 aa 18.3 kDa	No	0
AKT2-035 ENSP00000463262 ENST00000578615	J3QKW1 [Direct mapping] RAC-beta serine/threonine-protein kinase Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	292 aa 33.5 kDa	No	0
AKT2-036 ENSP00000462919 ENST00000578310	J3KTC6 [Direct mapping] RAC-beta serine/threonine-protein kinase Show all	Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	53 aa 5.9 kDa	No	0
AKT2-041 ENSP00000463368 ENST00000476247	J3QL45 [Direct mapping] RAC-beta serine/threonine-protein kinase Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	106 aa 12.4 kDa	No	0
AKT2-042 ENSP00000351095 ENST00000358335	A0A0A0MRF1 [Direct mapping] RAC-beta serine/threonine-protein kinase Show all	Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014) Show all		126 aa 14.7 kDa	No	0
AKT2-045 ENSP00000470604 ENST00000596634	M0QZK3 [Direct mapping] RAC-beta serine/threonine-protein kinase Show all	Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014) Show all		151 aa 17.5 kDa	No	0
AKT2-201 ENSP00000399532 ENST00000424901	P31751 [Direct mapping] RAC-beta serine/threonine-protein kinase Show all	Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0001934 [positive regulation of protein phosphorylation] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0005978 [glycogen biosynthetic process] GO:0006006 [glucose metabolic process] GO:0006417 [regulation of translation] GO:0006464 [cellular protein modification process] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0008286 [insulin receptor signaling pathway] GO:0008643 [carbohydrate transport] GO:0010748 [negative regulation of plasma membrane long-chain fatty acid transport] GO:0010907 [positive regulation of glucose metabolic process] GO:0030334 [regulation of cell migration] GO:0031340 [positive regulation of vesicle fusion] GO:0032000 [positive regulation of fatty acid beta-oxidation] GO:0032587 [ruffle membrane] GO:0032869 [cellular response to insulin stimulus] GO:0045444 [fat cell differentiation] GO:0045725 [positive regulation of glycogen biosynthetic process] GO:0046326 [positive regulation of glucose import] GO:0060644 [mammary gland epithelial cell differentiation] GO:0061024 [membrane organization] GO:0065002 [intracellular protein transmembrane transport] GO:0071156 [regulation of cell cycle arrest] GO:0090314 [positive regulation of protein targeting to membrane] GO:2000147 [positive regulation of cell motility] Show all	438 aa 51.1 kDa	No	0