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AKT2
  • TISSUE

  • premium

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  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

AKT2

Gene description

V-akt murine thymoma viral oncogene homolog 2

Protein class

Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

Intracellular

Number of transcripts

22
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Uncertain based on 1 antibody.
CAB004204
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
N/A
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

AKT2

Synonyms

Description

V-akt murine thymoma viral oncogene homolog 2 (HGNC Symbol)

Entrez gene summary

This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

q13.2

Chromosome location (bp)

40230317 - 40285536

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000105221 (version 83.38)

Entrez gene

208

UniProt

P31751 (UniProt - Evidence at protein level)

neXtProt

NX_P31751

Antibodypedia

AKT2 antibodies

PROTEIN BROWSER

«
AKT2-001
AKT2-005
AKT2-006
AKT2-007
AKT2-008
AKT2-010
AKT2-011
AKT2-012
AKT2-014
AKT2-021
AKT2-025
AKT2-027
AKT2-029
AKT2-030
AKT2-032
AKT2-033
AKT2-035
AKT2-036
AKT2-041
AKT2-042
AKT2-045
AKT2-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AKT2-001
ENSP00000375892
ENST00000392038
P31751 [Direct mapping]
RAC-beta serine/threonine-protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0005978 [glycogen biosynthetic process]
GO:0006006 [glucose metabolic process]
GO:0006417 [regulation of translation]
GO:0006464 [cellular protein modification process]
GO:0006468 [protein phosphorylation]
GO:0006970 [response to osmotic stress]
GO:0007165 [signal transduction]
GO:0008286 [insulin receptor signaling pathway]
GO:0008643 [carbohydrate transport]
GO:0009967 [positive regulation of signal transduction]
GO:0010628 [positive regulation of gene expression]
GO:0010748 [negative regulation of plasma membrane long-chain fatty acid transport]
GO:0010907 [positive regulation of glucose metabolic process]
GO:0014850 [response to muscle activity]
GO:0030334 [regulation of cell migration]
GO:0030335 [positive regulation of cell migration]
GO:0031340 [positive regulation of vesicle fusion]
GO:0031667 [response to nutrient levels]
GO:0031982 [vesicle]
GO:0032000 [positive regulation of fatty acid beta-oxidation]
GO:0032287 [peripheral nervous system myelin maintenance]
GO:0032587 [ruffle membrane]
GO:0032593 [insulin-responsive compartment]
GO:0032868 [response to insulin]
GO:0032869 [cellular response to insulin stimulus]
GO:0032870 [cellular response to hormone stimulus]
GO:0033119 [negative regulation of RNA splicing]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043491 [protein kinase B signaling]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045444 [fat cell differentiation]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046326 [positive regulation of glucose import]
GO:0050927 [positive regulation of positive chemotaxis]
GO:0060644 [mammary gland epithelial cell differentiation]
GO:0061024 [membrane organization]
GO:0065002 [intracellular protein transmembrane transport]
GO:0071156 [regulation of cell cycle arrest]
GO:0071407 [cellular response to organic cyclic compound]
GO:0072659 [protein localization to plasma membrane]
GO:0090314 [positive regulation of protein targeting to membrane]
GO:0090630 [activation of GTPase activity]
GO:2000147 [positive regulation of cell motility]
GO:2001275 [positive regulation of glucose import in response to insulin stimulus]
Show all
481 aa
55.8 kDa
No 0
AKT2-005
ENSP00000404083
ENST00000452077
E7EVP8 [Direct mapping]
RAC-beta serine/threonine-protein kinase
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
134 aa
15.7 kDa
No 0
AKT2-006
ENSP00000396532
ENST00000456441
C9JC83 [Direct mapping]
RAC-beta serine/threonine-protein kinase
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
107 aa
12.8 kDa
No 0
AKT2-007
ENSP00000403842
ENST00000423127
C9JIJ1 [Direct mapping]
RAC-beta serine/threonine-protein kinase
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
119 aa
14.1 kDa
No 0
AKT2-008
ENSP00000392458
ENST00000416994
C9J258 [Direct mapping]
RAC-beta serine/threonine-protein kinase
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
95 aa
11.3 kDa
No 0
AKT2-010
ENSP00000407999
ENST00000416362
A8MX96 [Direct mapping]
RAC-beta serine/threonine-protein kinase
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
133 aa
15.5 kDa
No 0
AKT2-011
ENSP00000403890
ENST00000427375
C9JIF6 [Direct mapping]
RAC-beta serine/threonine-protein kinase
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
67 aa
7.9 kDa
No 0
AKT2-012
ENSP00000396968
ENST00000441941
C9JHS6 [Direct mapping]
RAC-beta serine/threonine-protein kinase
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
184 aa
21.3 kDa
No 0
AKT2-014
ENSP00000375891
ENST00000392037
A8MX96 [Direct mapping]
RAC-beta serine/threonine-protein kinase
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
133 aa
15.5 kDa
No 0
AKT2-021
ENSP00000472382
ENST00000497948
M0R283 [Direct mapping]
RAC-beta serine/threonine-protein kinase
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
117 aa
13.1 kDa
No 0
AKT2-025
ENSP00000471369
ENST00000579047
M0R0P9 [Direct mapping]
RAC-beta serine/threonine-protein kinase
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
450 aa
51.6 kDa
No 0
AKT2-027
ENSP00000309428
ENST00000311278
P31751 [Direct mapping]
RAC-beta serine/threonine-protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0005978 [glycogen biosynthetic process]
GO:0006006 [glucose metabolic process]
GO:0006417 [regulation of translation]
GO:0006464 [cellular protein modification process]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0008286 [insulin receptor signaling pathway]
GO:0008643 [carbohydrate transport]
GO:0010748 [negative regulation of plasma membrane long-chain fatty acid transport]
GO:0010907 [positive regulation of glucose metabolic process]
GO:0030334 [regulation of cell migration]
GO:0031340 [positive regulation of vesicle fusion]
GO:0032000 [positive regulation of fatty acid beta-oxidation]
GO:0032587 [ruffle membrane]
GO:0032869 [cellular response to insulin stimulus]
GO:0045444 [fat cell differentiation]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0046326 [positive regulation of glucose import]
GO:0060644 [mammary gland epithelial cell differentiation]
GO:0061024 [membrane organization]
GO:0065002 [intracellular protein transmembrane transport]
GO:0071156 [regulation of cell cycle arrest]
GO:0090314 [positive regulation of protein targeting to membrane]
GO:2000147 [positive regulation of cell motility]
Show all
438 aa
51.1 kDa
No 0
AKT2-029
ENSP00000462022
ENST00000578123
J3KRI8 [Direct mapping]
RAC-beta serine/threonine-protein kinase
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
130 aa
15.2 kDa
No 0
AKT2-030
ENSP00000462715
ENST00000583859
J3KSY8 [Direct mapping]
RAC-beta serine/threonine-protein kinase
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
99 aa
11.9 kDa
No 0
AKT2-032
ENSP00000463806
ENST00000580747
C9J258 [Direct mapping]
RAC-beta serine/threonine-protein kinase
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
95 aa
11.3 kDa
No 0
AKT2-033
ENSP00000463686
ENST00000486368
J3QLS6 [Direct mapping]
RAC-beta serine/threonine-protein kinase
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
157 aa
18.3 kDa
No 0
AKT2-035
ENSP00000463262
ENST00000578615
J3QKW1 [Direct mapping]
RAC-beta serine/threonine-protein kinase
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
292 aa
33.5 kDa
No 0
AKT2-036
ENSP00000462919
ENST00000578310
J3KTC6 [Direct mapping]
RAC-beta serine/threonine-protein kinase
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
53 aa
5.9 kDa
No 0
AKT2-041
ENSP00000463368
ENST00000476247
J3QL45 [Direct mapping]
RAC-beta serine/threonine-protein kinase
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
106 aa
12.4 kDa
No 0
AKT2-042
ENSP00000351095
ENST00000358335
A0A0A0MRF1 [Direct mapping]
RAC-beta serine/threonine-protein kinase
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
126 aa
14.7 kDa
No 0
AKT2-045
ENSP00000470604
ENST00000596634
M0QZK3 [Direct mapping]
RAC-beta serine/threonine-protein kinase
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
151 aa
17.5 kDa
No 0
AKT2-201
ENSP00000399532
ENST00000424901
P31751 [Direct mapping]
RAC-beta serine/threonine-protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0005978 [glycogen biosynthetic process]
GO:0006006 [glucose metabolic process]
GO:0006417 [regulation of translation]
GO:0006464 [cellular protein modification process]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0008286 [insulin receptor signaling pathway]
GO:0008643 [carbohydrate transport]
GO:0010748 [negative regulation of plasma membrane long-chain fatty acid transport]
GO:0010907 [positive regulation of glucose metabolic process]
GO:0030334 [regulation of cell migration]
GO:0031340 [positive regulation of vesicle fusion]
GO:0032000 [positive regulation of fatty acid beta-oxidation]
GO:0032587 [ruffle membrane]
GO:0032869 [cellular response to insulin stimulus]
GO:0045444 [fat cell differentiation]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0046326 [positive regulation of glucose import]
GO:0060644 [mammary gland epithelial cell differentiation]
GO:0061024 [membrane organization]
GO:0065002 [intracellular protein transmembrane transport]
GO:0071156 [regulation of cell cycle arrest]
GO:0090314 [positive regulation of protein targeting to membrane]
GO:2000147 [positive regulation of cell motility]
Show all
438 aa
51.1 kDa
No 0

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