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SLC1A5

GENERAL INFORMATION

Gene name

 SLC1A5

Gene description

 Solute carrier family 1 (neutral amino acid transporter), member 5

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Membranous and cytoplasmic expression in most cell types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA035239 , HPA035240
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (unfavourable).
Liver cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Urothelial cancer

STAINING SUMMARY
HPA035239
HPA035240

GENE INFORMATION

Gene name

 SLC1A5 (HGNC Symbol)

Synonyms

 AAAT, ASCT2, M7V1, RDRC

Description

 Solute carrier family 1 (neutral amino acid transporter), member 5 (HGNC Symbol)

Entrez gene summary

 The SLC1A5 gene encodes a sodium-dependent neutral amino acid transporter that can act as a receptor for RD114/type D retrovirus (Larriba et al., 2001 [PubMed 11781704]).[supplied by OMIM, Jan 2011]

Chromosome

 19

Cytoband

 q13.32

Chromosome location (bp)

 46774883 - 46788594

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105281 (version 83.38)

Entrez gene

 6510

UniProt

 Q15758 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15758

Antibodypedia

 SLC1A5 antibodies

PROTEIN BROWSER
SLC1A5-001
SLC1A5-003
SLC1A5-004
SLC1A5-005
SLC1A5-006
SLC1A5-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC1A5-001
ENSP00000444408
ENST00000542575
Q15758 [Direct mapping]
Neutral amino acid transporter B(0)
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006835 [dicarboxylic acid transport]
GO:0006865 [amino acid transport]
GO:0006868 [glutamine transport]
GO:0015175 [neutral amino acid transmembrane transporter activity]
GO:0015186 [L-glutamine transmembrane transporter activity]
GO:0015804 [neutral amino acid transport]
GO:0016020 [membrane]
GO:0017153 [sodium:dicarboxylate symporter activity]
GO:0042470 [melanosome]
GO:0046718 [viral entry into host cell]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
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 541 aa
56.6 kDa 		No 9
SLC1A5-003
ENSP00000469265
ENST00000594991
M0QXM4 [Direct mapping]
Amino acid transporter
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006835 [dicarboxylic acid transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017153 [sodium:dicarboxylate symporter activity]
GO:0055085 [transmembrane transport]
Show all
 365 aa
39.4 kDa 		No 6
SLC1A5-004
ENSP00000406532
ENST00000434726
Q15758 [Direct mapping]
Neutral amino acid transporter B(0)
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006835 [dicarboxylic acid transport]
GO:0006865 [amino acid transport]
GO:0006868 [glutamine transport]
GO:0015175 [neutral amino acid transmembrane transporter activity]
GO:0015186 [L-glutamine transmembrane transporter activity]
GO:0015804 [neutral amino acid transport]
GO:0016020 [membrane]
GO:0017153 [sodium:dicarboxylate symporter activity]
GO:0042470 [melanosome]
GO:0046718 [viral entry into host cell]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
Show all
 339 aa
36.6 kDa 		No 6
SLC1A5-005
ENSP00000397924
ENST00000412532
Q15758 [Direct mapping]
Neutral amino acid transporter B(0)
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006835 [dicarboxylic acid transport]
GO:0006865 [amino acid transport]
GO:0006868 [glutamine transport]
GO:0015175 [neutral amino acid transmembrane transporter activity]
GO:0015186 [L-glutamine transmembrane transporter activity]
GO:0015804 [neutral amino acid transport]
GO:0016020 [membrane]
GO:0017153 [sodium:dicarboxylate symporter activity]
GO:0042470 [melanosome]
GO:0046718 [viral entry into host cell]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
Show all
 313 aa
33.7 kDa 		No 5
SLC1A5-006
ENSP00000471626
ENST00000598022
M0R144 [Direct mapping]
Neutral amino acid transporter B(0)
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006835 [dicarboxylic acid transport]
GO:0016020 [membrane]
GO:0017153 [sodium:dicarboxylate symporter activity]
Show all
 29 aa
3.1 kDa 		No 0
SLC1A5-007
ENSP00000468890
ENST00000593713
M0QX44 [Direct mapping]
Amino acid transporter
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006835 [dicarboxylic acid transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017153 [sodium:dicarboxylate symporter activity]
GO:0055085 [transmembrane transport]
Show all
 259 aa
28.1 kDa 		No 4

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.