Cell atlas - PLIN3 - The Human Protein Atlas

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PLIN3

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Lipid droplets

Human cell
	Cytosol
	Vesicles

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GENERAL INFORMATION
Gene name	PLIN3
Gene description	Perilipin 3
Protein class	FDA approved drug targets Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the lipid droplets. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Lipid droplets (validated)
Additional location	In addition localized to the Cytosol (supported)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA006427 , HPA066538
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the lipid droplets. In addition localized to the cytosol.

Main location

Lipid droplets (validated)

Additional location

Cytosol (supported)


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Antibody	Cell line	Location
HPA006427	A-431	Lipid droplets
HPA006427	U-2 OS	Lipid droplets
HPA006427	U-2 OS	Cytosol
HPA006427	U-251 MG	Lipid droplets
HPA006427	U-251 MG	Cytosol
HPA066538	A-431	Lipid droplets
HPA066538	PC-3	Lipid droplets
HPA066538	U-2 OS	Lipid droplets

GENE INFORMATION
Gene name	PLIN3 (HGNC Symbol)
Synonyms	M6PRBP1, PP17, TIP47
Description	Perilipin 3 (HGNC Symbol)
Entrez gene summary	Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2009]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	4838341 - 4867768
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105355 (version 83.38)
Entrez gene	10226
UniProt	O60664 (UniProt - Evidence at protein level)
neXtProt	NX_O60664
Antibodypedia	PLIN3 antibodies

PROTEIN BROWSER

PLIN3-001	PLIN3-002	PLIN3-003	PLIN3-004	PLIN3-005	PLIN3-007	PLIN3-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLIN3-001 ENSP00000221957 ENST00000221957	O60664 [Direct mapping] Perilipin-3 Show all	Predicted intracellular proteins Plasma proteins FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005794 [Golgi apparatus] GO:0005811 [lipid particle] GO:0010008 [endosome membrane] GO:0016020 [membrane] GO:0016192 [vesicle-mediated transport] GO:0043231 [intracellular membrane-bounded organelle] Show all	434 aa 47.1 kDa	No	0
PLIN3-002 ENSP00000468096 ENST00000589494	K7ER39 [Direct mapping] Perilipin-3 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		168 aa 17.6 kDa	No	0
PLIN3-003 ENSP00000465117 ENST00000587462	K7EJD0 [Direct mapping] Perilipin-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		35 aa 3.6 kDa	No	0
PLIN3-004 ENSP00000465975 ENST00000589034	K7EL96 [Direct mapping] Perilipin-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		173 aa 18.1 kDa	No	0
PLIN3-005 ENSP00000468476 ENST00000589163	K7ERZ3 [Direct mapping] Perilipin-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		292 aa 31.9 kDa	No	0
PLIN3-007 ENSP00000467803 ENST00000592528	O60664 [Direct mapping] Perilipin-3 Show all	Predicted intracellular proteins Plasma proteins FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005794 [Golgi apparatus] GO:0005811 [lipid particle] GO:0010008 [endosome membrane] GO:0016020 [membrane] GO:0016192 [vesicle-mediated transport] GO:0043231 [intracellular membrane-bounded organelle] Show all	422 aa 45.8 kDa	No	0
PLIN3-008 ENSP00000465596 ENST00000585479	O60664 [Direct mapping] Perilipin-3 Show all	Predicted intracellular proteins Plasma proteins FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005794 [Golgi apparatus] GO:0005811 [lipid particle] GO:0010008 [endosome membrane] GO:0016020 [membrane] GO:0016192 [vesicle-mediated transport] GO:0043231 [intracellular membrane-bounded organelle] Show all	433 aa 46.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.