Expression of PLIN3 in cancer - Summary - The Human Protein Atlas

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PLIN3

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PLIN3
Gene description	Perilipin 3
Protein class	FDA approved drug targets Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several different tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Uncertain based on 2 antibodies. HPA006427 , HPA066538
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), lung cancer (unfavourable), liver cancer (unfavourable) and endometrial cancer (favourable).
Renal cancer p<0.001 Lung cancer p<0.001 Liver cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA006427	HPA066538

GENE INFORMATION
Gene name	PLIN3 (HGNC Symbol)
Synonyms	M6PRBP1, PP17, TIP47
Description	Perilipin 3 (HGNC Symbol)
Entrez gene summary	Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2009]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	4838341 - 4867768
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105355 (version 83.38)
Entrez gene	10226
UniProt	O60664 (UniProt - Evidence at protein level)
neXtProt	NX_O60664
Antibodypedia	PLIN3 antibodies

PROTEIN BROWSER

PLIN3-001	PLIN3-002	PLIN3-003	PLIN3-004	PLIN3-005	PLIN3-007	PLIN3-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLIN3-001 ENSP00000221957 ENST00000221957	O60664 [Direct mapping] Perilipin-3 Show all	Predicted intracellular proteins Plasma proteins FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005794 [Golgi apparatus] GO:0005811 [lipid particle] GO:0010008 [endosome membrane] GO:0016020 [membrane] GO:0016192 [vesicle-mediated transport] GO:0043231 [intracellular membrane-bounded organelle] Show all	434 aa 47.1 kDa	No	0
PLIN3-002 ENSP00000468096 ENST00000589494	K7ER39 [Direct mapping] Perilipin-3 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		168 aa 17.6 kDa	No	0
PLIN3-003 ENSP00000465117 ENST00000587462	K7EJD0 [Direct mapping] Perilipin-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		35 aa 3.6 kDa	No	0
PLIN3-004 ENSP00000465975 ENST00000589034	K7EL96 [Direct mapping] Perilipin-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		173 aa 18.1 kDa	No	0
PLIN3-005 ENSP00000468476 ENST00000589163	K7ERZ3 [Direct mapping] Perilipin-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		292 aa 31.9 kDa	No	0
PLIN3-007 ENSP00000467803 ENST00000592528	O60664 [Direct mapping] Perilipin-3 Show all	Predicted intracellular proteins Plasma proteins FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005794 [Golgi apparatus] GO:0005811 [lipid particle] GO:0010008 [endosome membrane] GO:0016020 [membrane] GO:0016192 [vesicle-mediated transport] GO:0043231 [intracellular membrane-bounded organelle] Show all	422 aa 45.8 kDa	No	0
PLIN3-008 ENSP00000465596 ENST00000585479	O60664 [Direct mapping] Perilipin-3 Show all	Predicted intracellular proteins Plasma proteins FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005794 [Golgi apparatus] GO:0005811 [lipid particle] GO:0010008 [endosome membrane] GO:0016020 [membrane] GO:0016192 [vesicle-mediated transport] GO:0043231 [intracellular membrane-bounded organelle] Show all	433 aa 46.9 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.