Expression of CEACAM5 in cancer - Summary

GENERAL INFORMATION
Gene name	CEACAM5
Gene description	Carcinoembryonic antigen-related cell adhesion molecule 5
Protein class	Cancer-related genes CD markers Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (colorectal cancer)
HPA (cell line):	Cell line enriched (HaCaT)
HPA (normal tissue):	Tissue enhanced (colon, rectum)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective membranous and cytoplasmic expression in gastrointestinal tract and squamous epithelia. Most abundant in large intestine.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 4 antibodies. HPA011041 , HPA019758 , CAB000021 , CAB000022
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (colorectal cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA011041	HPA019758	CAB000021	CAB000022

GENE INFORMATION
Gene name	CEACAM5 (HGNC Symbol)
Synonyms	CD66e, CEA
Description	Carcinoembryonic antigen-related cell adhesion molecule 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	41708585 - 41729798
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105388 (version 83.38)
Entrez gene	1048
UniProt	P06731 (UniProt - Evidence at protein level)
neXtProt	NX_P06731
Antibodypedia	CEACAM5 antibodies

PROTEIN BROWSER

CEACAM5-001	CEACAM5-002	CEACAM5-003	CEACAM5-006	CEACAM5-007	CEACAM5-201	CEACAM5-202	CEACAM5-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CEACAM5-001 ENSP00000221992 ENST00000221992	P06731 [Direct mapping] Carcinoembryonic antigen-related cell adhesion molecule 5 Show all	CD markers MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0010832 [negative regulation of myotube differentiation] GO:0016323 [basolateral plasma membrane] GO:0031225 [anchored component of membrane] GO:0034109 [homotypic cell-cell adhesion] GO:0034235 [GPI anchor binding] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0070062 [extracellular exosome] GO:0071575 [integral component of external side of plasma membrane] GO:2000811 [negative regulation of anoikis] Show all	702 aa 76.8 kDa	Yes	0
CEACAM5-002 ENSP00000381600 ENST00000398599	P06731 [Direct mapping] Carcinoembryonic antigen-related cell adhesion molecule 5 Show all	CD markers MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0010832 [negative regulation of myotube differentiation] GO:0016323 [basolateral plasma membrane] GO:0031225 [anchored component of membrane] GO:0034109 [homotypic cell-cell adhesion] GO:0034235 [GPI anchor binding] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0070062 [extracellular exosome] GO:0071575 [integral component of external side of plasma membrane] GO:2000811 [negative regulation of anoikis] Show all	701 aa 76.7 kDa	Yes	0
CEACAM5-003 ENSP00000385072 ENST00000405816	P06731 [Direct mapping] Carcinoembryonic antigen-related cell adhesion molecule 5 Show all	CD markers MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0010832 [negative regulation of myotube differentiation] GO:0016323 [basolateral plasma membrane] GO:0031225 [anchored component of membrane] GO:0034109 [homotypic cell-cell adhesion] GO:0034235 [GPI anchor binding] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0070062 [extracellular exosome] GO:0071575 [integral component of external side of plasma membrane] GO:2000811 [negative regulation of anoikis] Show all	702 aa 76.8 kDa	Yes	0
CEACAM5-006 ENSP00000473252 ENST00000595113	M0R3J1 [Direct mapping] Carcinoembryonic antigen-related cell adhesion molecule 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	194 aa 21.7 kDa	No	0
CEACAM5-007 ENSP00000468997 ENST00000595403	M0QX98 [Direct mapping] Carcinoembryonic antigen-related cell adhesion molecule 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	141 aa 15.6 kDa	No	0
CEACAM5-201 ENSP00000482157 ENST00000615021	A0A087WYX0 [Direct mapping] Carcinoembryonic antigen-related cell adhesion molecule 5 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	524 aa 57.2 kDa	Yes	0
CEACAM5-202 ENSP00000480800 ENST00000616453	T2HUW8 [Direct mapping] Carcinoembryonic antigen-related cell adhesion molecule 5; Carcinoembryonic antigen-related cell adhesion molecule 5 isoform 3D Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	346 aa 37.7 kDa	Yes	0
CEACAM5-203 ENSP00000482303 ENST00000617332	A0A024R0K5 [Direct mapping] Carcinoembryonic antigen-related cell adhesion molecule 5; Carcinoembryonic antigen-related cell adhesion molecule 5, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	702 aa 76.8 kDa	Yes	0