Cell atlas - GRWD1 - The Human Protein Atlas

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GRWD1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli
	Nucleus

Human cell
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	GRWD1
Gene description	Glutamate-rich WD repeat containing 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoli. In addition localized to the nucleus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (supported)
Additional location	In addition localized to the Nucleus (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA042643 , HPA055680
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoli. In addition localized to the nucleus.

Main location

Nucleoli (supported)

Additional location

Nucleus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
HPA042643	A-431	Nucleus	Intensity
		Nucleoli	Intensity
		Cytosol
HPA042643	U-2 OS	Nucleus
		Nucleoli
		Cytosol
HPA042643	U-251 MG	Nucleus
		Nucleoli
		Cytosol
HPA055680	A-431	Nucleus
HPA055680	A-431	Nucleoli
HPA055680	U-2 OS	Nucleus
HPA055680	U-2 OS	Nucleoli
HPA055680	U-251 MG	Nucleus
HPA055680	U-251 MG	Nucleoli

GENE INFORMATION
Gene name	GRWD1 (HGNC Symbol)
Synonyms	GRWD, RRB1, WDR28
Description	Glutamate-rich WD repeat containing 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a glutamate-rich protein that contains five WD-repeat motifs. The encoded protein may play a critical role in ribosome biogenesis and may also play a role in histone methylation through interactions with CUL4-DDB1 ubiquitin E3 ligase. [provided by RefSeq, Feb 2012]
Chromosome	19
Cytoband	q13.33
Chromosome location (bp)	48445773 - 48457022
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105447 (version 83.38)
Entrez gene	83743
UniProt	Q9BQ67 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BQ67
Antibodypedia	GRWD1 antibodies

PROTEIN BROWSER

GRWD1-001	GRWD1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GRWD1-001 ENSP00000253237 ENST00000253237	Q9BQ67 [Direct mapping] Glutamate-rich WD repeat-containing protein 1 A0MNN5 [Target identity:100%; Query identity:100%] CDW4/GRWD1; Glutamate-rich WD repeat containing 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0044822 [poly(A) RNA binding] Show all	446 aa 49.4 kDa	No	0
GRWD1-002 ENSP00000468943 ENST00000598711	M0QX71 [Direct mapping] Glutamate-rich WD repeat-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] Show all	228 aa 25.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.