Expression of GRWD1 in cancer - Summary - The Human Protein Atlas

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GRWD1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GRWD1
Gene description	Glutamate-rich WD repeat containing 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear and cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA042643
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA042643

GENE INFORMATION
Gene name	GRWD1 (HGNC Symbol)
Synonyms	GRWD, RRB1, WDR28
Description	Glutamate-rich WD repeat containing 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a glutamate-rich protein that contains five WD-repeat motifs. The encoded protein may play a critical role in ribosome biogenesis and may also play a role in histone methylation through interactions with CUL4-DDB1 ubiquitin E3 ligase. [provided by RefSeq, Feb 2012]
Chromosome	19
Cytoband	q13.33
Chromosome location (bp)	48445773 - 48457022
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105447 (version 83.38)
Entrez gene	83743
UniProt	Q9BQ67 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BQ67
Antibodypedia	GRWD1 antibodies

PROTEIN BROWSER

GRWD1-001	GRWD1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GRWD1-001 ENSP00000253237 ENST00000253237	Q9BQ67 [Direct mapping] Glutamate-rich WD repeat-containing protein 1 A0MNN5 [Target identity:100%; Query identity:100%] CDW4/GRWD1; Glutamate-rich WD repeat containing 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0044822 [poly(A) RNA binding] Show all	446 aa 49.4 kDa	No	0
GRWD1-002 ENSP00000468943 ENST00000598711	M0QX71 [Direct mapping] Glutamate-rich WD repeat-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] Show all	228 aa 25.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.