Expression of MIER2 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

MIER2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MIER2
Gene description	Mesoderm induction early response 1, family member 2
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA041439
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), endometrial cancer (favourable) and colorectal cancer (unfavourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041439

GENE INFORMATION
Gene name	MIER2 (HGNC Symbol)
Synonyms	KIAA1193
Description	Mesoderm induction early response 1, family member 2 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	301444 - 344807
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105556 (version 83.38)
Entrez gene	54531
UniProt	Q8N344 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N344
Antibodypedia	MIER2 antibodies

PROTEIN BROWSER

MIER2-001	MIER2-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MIER2-001 ENSP00000264819 ENST00000264819	Q8N344 [Direct mapping] Mesoderm induction early response protein 2 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	545 aa 59.9 kDa	No	0
MIER2-006 ENSP00000482489 ENST00000619835	A0A087WZA4 [Direct mapping] Mesoderm induction early response protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		210 aa 22.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.