Cell atlas - KCNN1 - The Human Protein Atlas

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KCNN1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Actin filaments
	Cytosol

Human cell
	Actin Filaments
	Cytosol

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GENERAL INFORMATION
Gene name	KCNN1
Gene description	Potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
Protein class	Predicted intracellular proteins Predicted membrane proteins Voltage-gated ion channels
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & actin filaments.
RNA cell category	Cell line enriched (REH)
Protein evidence	Evidence at protein level
Main location	Localized to the Actin filaments (approved), Cytosol (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA065938
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (REH) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & actin filaments.

Main location

Actin filaments (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA065938	HEK 293	Actin filaments	Spatial
	HPA065938	HEK 293	Cytosol
	HPA065938	SH-SY5Y	Actin filaments	Spatial
	HPA065938	SH-SY5Y	Cytosol
	HPA065938	U-2 OS	Actin filaments	Spatial
	HPA065938	U-2 OS	Cytosol	Intensity

GENE INFORMATION
Gene name	KCNN1 (HGNC Symbol)
Synonyms	hSK1, KCa2.1
Description	Potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 (HGNC Symbol)
Entrez gene summary	Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.11
Chromosome location (bp)	17951293 - 18000080
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105642 (version 83.38)
Entrez gene	3780
UniProt	Q92952 (UniProt - Evidence at transcript level)
neXtProt	NX_Q92952
Antibodypedia	KCNN1 antibodies

PROTEIN BROWSER

KCNN1-001	KCNN1-004	KCNN1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNN1-001 ENSP00000476519 ENST00000222249	Q92952 [Direct mapping] Small conductance calcium-activated potassium channel protein 1 Show all	Voltage-gated ion channels Calcium-Activated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005516 [calmodulin binding] GO:0005886 [plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0008076 [voltage-gated potassium channel complex] GO:0015269 [calcium-activated potassium channel activity] GO:0016021 [integral component of membrane] GO:0016286 [small conductance calcium-activated potassium channel activity] GO:0043025 [neuronal cell body] GO:0046982 [protein heterodimerization activity] GO:0071805 [potassium ion transmembrane transport] Show all	543 aa 60 kDa	No	5
KCNN1-004 ENSP00000477114 ENST00000609922	V9GYV2 [Direct mapping] Small conductance calcium-activated potassium channel protein 1 Show all	Predicted intracellular proteins Show all	GO:0005516 [calmodulin binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0016286 [small conductance calcium-activated potassium channel activity] GO:0043025 [neuronal cell body] GO:0071805 [potassium ion transmembrane transport] Show all	158 aa 16.2 kDa	No	0
KCNN1-201 ENSP00000484926 ENST00000615435	A0A087X2E7 [Direct mapping] Small conductance calcium-activated potassium channel protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0005516 [calmodulin binding] GO:0005886 [plasma membrane] GO:0006813 [potassium ion transport] GO:0015269 [calcium-activated potassium channel activity] GO:0016021 [integral component of membrane] GO:0016286 [small conductance calcium-activated potassium channel activity] GO:0043025 [neuronal cell body] GO:0071805 [potassium ion transmembrane transport] Show all	543 aa 60 kDa	No	5

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.