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KCNN1
  • TISSUE

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PATHOLOGY ATLAS

GENE/PROTEIN

Dictionary

GENERAL INFORMATION

Gene name

KCNN1

Gene description

Potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1

Protein class

Predicted intracellular proteins
Predicted membrane proteins
Voltage-gated ion channels

Predicted localization

Intracellular,Membrane

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enhanced (testis cancer)
HPA (cell line):Cell line enriched (REH)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

Pending cancer tissue analysis.

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enhanced (testis cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis


STAINING SUMMARY

 

GENE INFORMATION

Gene name

KCNN1 (HGNC Symbol)

Synonyms

hSK1, KCa2.1

Description

Potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 (HGNC Symbol)

Entrez gene summary

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

p13.11

Chromosome location (bp)

17951293 - 18000080

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000105642 (version 83.38)

Entrez gene

3780

UniProt

Q92952 (UniProt - Evidence at transcript level)

neXtProt

NX_Q92952

Antibodypedia

KCNN1 antibodies

PROTEIN BROWSER

KCNN1-001
KCNN1-004
KCNN1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KCNN1-001
ENSP00000476519
ENST00000222249
Q92952 [Direct mapping]
Small conductance calcium-activated potassium channel protein 1
Show all
Voltage-gated ion channels
   Calcium-Activated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005516 [calmodulin binding]
GO:0005886 [plasma membrane]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0015269 [calcium-activated potassium channel activity]
GO:0016021 [integral component of membrane]
GO:0016286 [small conductance calcium-activated potassium channel activity]
GO:0043025 [neuronal cell body]
GO:0046982 [protein heterodimerization activity]
GO:0071805 [potassium ion transmembrane transport]
Show all
543 aa
60 kDa
No 5
KCNN1-004
ENSP00000477114
ENST00000609922
V9GYV2 [Direct mapping]
Small conductance calcium-activated potassium channel protein 1
Show all
Predicted intracellular proteins
Show all
GO:0005516 [calmodulin binding]
GO:0005886 [plasma membrane]
GO:0016021 [integral component of membrane]
GO:0016286 [small conductance calcium-activated potassium channel activity]
GO:0043025 [neuronal cell body]
GO:0071805 [potassium ion transmembrane transport]
Show all
158 aa
16.2 kDa
No 0
KCNN1-201
ENSP00000484926
ENST00000615435
A0A087X2E7 [Direct mapping]
Small conductance calcium-activated potassium channel protein 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Show all
GO:0005516 [calmodulin binding]
GO:0005886 [plasma membrane]
GO:0006813 [potassium ion transport]
GO:0015269 [calcium-activated potassium channel activity]
GO:0016021 [integral component of membrane]
GO:0016286 [small conductance calcium-activated potassium channel activity]
GO:0043025 [neuronal cell body]
GO:0071805 [potassium ion transmembrane transport]
Show all
543 aa
60 kDa
No 5

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