Expression of DDX49 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

DDX49

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DDX49
Gene description	DEAD (Asp-Glu-Ala-Asp) box polypeptide 49
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous granular cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA041870 , HPA048093
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable), renal cancer (unfavourable) and liver cancer (unfavourable).
Cervical cancer p<0.001 Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041870	HPA048093

GENE INFORMATION
Gene name	DDX49 (HGNC Symbol)
Synonyms	FLJ10432
Description	DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	p13.11
Chromosome location (bp)	18919675 - 18928633
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105671 (version 83.38)
Entrez gene	54555
UniProt	Q9Y6V7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y6V7
Antibodypedia	DDX49 antibodies

PROTEIN BROWSER

DDX49-001	DDX49-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DDX49-001 ENSP00000247003 ENST00000247003	Q9Y6V7 [Direct mapping] Probable ATP-dependent RNA helicase DDX49 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0010501 [RNA secondary structure unwinding] GO:0044822 [poly(A) RNA binding] Show all	483 aa 54.2 kDa	No	0
DDX49-201 ENSP00000487048 ENST00000629999	M0R0K1 [Direct mapping] DEAD (Asp-Glu-Ala-Asp) box polypeptide 49, isoform CRA_c; Probable ATP-dependent RNA helicase DDX49 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0010501 [RNA secondary structure unwinding] Show all	166 aa 17.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.