Expression of TMEM59L in cancer - Summary - The Human Protein Atlas

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TMEM59L

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TMEM59L
Gene description	Transmembrane protein 59-like
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (glioma)
HPA (cell line):	Group enriched (AN3-CA, EFO-21, Hep G2, SH-SY5Y, U-2 OS)
HPA (normal tissue):	Tissue enriched (cerebral cortex)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Cytoplasmic expression with a granular pattern in CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA010661
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable) and pancreatic cancer (favourable).
Endometrial cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA010661

GENE INFORMATION
Gene name	TMEM59L (HGNC Symbol)
Synonyms	BSMAP, C19orf4
Description	Transmembrane protein 59-like (HGNC Symbol)
Entrez gene summary	This gene encodes a predicted type-I membrane glycoprotein. The encoded protein may play a role in functioning of the central nervous system. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.11
Chromosome location (bp)	18607430 - 18621039
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000105696 (version 83.38)
Entrez gene	25789
UniProt	Q9UK28 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9UK28
Antibodypedia	TMEM59L antibodies

PROTEIN BROWSER

TMEM59L-001	TMEM59L-005	TMEM59L-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMEM59L-001 ENSP00000470879 ENST00000600490	Q9UK28 [Direct mapping] Transmembrane protein 59-like A0A024R7L4 [Target identity:100%; Query identity:100%] Chromosome 19 open reading frame 4, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0000139 [Golgi membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	342 aa 37.6 kDa	Yes	1
TMEM59L-005 ENSP00000471612 ENST00000594709	M0R134 [Direct mapping] Transmembrane protein 59-like Show all	Predicted intracellular proteins Show all		134 aa 14.3 kDa	No	0
TMEM59L-201 ENSP00000262817 ENST00000262817	Q9UK28 [Direct mapping] Transmembrane protein 59-like A0A024R7L4 [Target identity:100%; Query identity:100%] Chromosome 19 open reading frame 4, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0000139 [Golgi membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	342 aa 37.6 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.